| Transactions | ||||||
| Date | Team | Player | Type | OthTm | EffDate | When |
| 5/13/2010 | CRH | Francisco,F | Demoted to reserve roster | Before | ||
| 5/19/2010 | GEO | Davis,C | Traded away | MAD | After | |
| 5/19/2010 | GEO | Hamilton,J | Acquired via trade | MAD | After | |
| 5/19/2010 | MAD | Davis,C | Acquired via trade | GEO | After | |
| 5/19/2010 | MAD | Hamilton,J | Traded away | GEO | After | |
| 5/26/2010 | BON | Crain | Traded away | LON | After | |
| 5/26/2010 | BON | Gallardo | Acquired via trade | LON | After | |
| 5/26/2010 | LON | Crain | Acquired via trade | BON | After | |
| 5/26/2010 | LON | Gallardo | Traded away | BON | After | |
| 6/30/2010 | COP | Hughes,P | Traded away | CRH | After | |
| 6/30/2010 | COP | Lee,Ca | Acquired via trade | CRH | After | |
| 6/30/2010 | CRH | Hughes,P | Acquired via trade | COP | After | |
| 6/30/2010 | CRH | Lee,Ca | Traded away | COP | After | |
| 7/1/2010 | COP | Lee,Ca | Demoted to reserve roster | Before | ||
| 7/1/2010 | COP | Marcum | Promoted to active roster | Before | ||
| 7/8/2010 | MID | Quintero | Signed | Before | ||
| 8/12/2010 | MID | Gomez,C | Demoted to reserve roster | Before | ||
| 8/12/2010 | MID | Hill,A | Demoted to reserve roster | Before | ||
| 8/12/2010 | TON | Johnson,C | Demoted to reserve roster | Before | ||