| Transactions | ||||||
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/2/2008 | MAD | Beltre | Traded away | TON | After | |
| 4/2/2008 | MAD | Burrell | Acquired via trade | TON | After | |
| 4/2/2008 | MAD | Drew,S | Acquired via trade | TON | After | |
| 4/2/2008 | MAD | Hardy | Traded away | TON | After | |
| 4/2/2008 | MAD | Loney | Acquired via trade | BT | After | |
| 4/2/2008 | MAD | Pierre | Traded away | BT | After | |
| 4/2/2008 | MAD | Ramirez,Ar | Acquired via trade | TON | After | |
| 4/17/2008 | BON | Gonzalez,C | Demoted to reserve roster | Before | ||
| 4/17/2008 | BON | Neshek | Demoted to reserve roster | Before | ||
| 4/17/2008 | BON | Perkins | Demoted to reserve roster | Before | ||
| 4/17/2008 | BON | Tejada,M | Demoted to reserve roster | Before | ||
| 5/14/2008 | CCL | Rollins | Traded away | MID | After | |
| 5/14/2008 | CCL | Young,M | Acquired via trade | MID | After | |
| 5/15/2008 | Pal | Jacobs | Promoted to active roster | Before | ||
| 6/4/2008 | ROK | Devine | Traded away | BT | After | |
| 6/4/2008 | ROK | Wuertz | Acquired via trade | BT | After | |
| 7/9/2026 | BON | Bay | Acquired via trade | Pal | After | |
| 7/9/2026 | BON | Swisher | Traded away | Pal | After | |
| 7/9/2026 | Pal | Bay | Traded away | BON | After | |
| 7/9/2026 | Pal | Swisher | Acquired via trade | BON | After | |