| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 1/30/2016 | End | McHugh | Acquired via trade | SS | | After |
| 1/30/2016 | End | Uehara | Acquired via trade | SS | | After |
| 1/30/2016 | End | Ventura | Traded away | SS | | After |
| 1/30/2016 | SS | McHugh | Traded away | End | | After |
| 1/30/2016 | SS | Uehara | Traded away | End | | After |
| 1/30/2016 | SS | Ventura | Acquired via trade | End | | After |
| 2/2/2016 | ACS | Ackley | Acquired via trade | SFR | | After |
| 2/2/2016 | ACS | Adams,M | Acquired via trade | SFR | | After |
| 2/2/2016 | ACS | Alvarez,P | Acquired via trade | SFR | | After |
| 2/2/2016 | ACS | Bour | Acquired via trade | FH | | After |
| 2/2/2016 | ACS | Duffey | Traded away | SFR | | After |
| 2/2/2016 | ACS | Gomes,Y | Acquired via trade | SFR | | After |
| 2/2/2016 | ACS | Kela | Traded away | SFR | | After |
| 2/2/2016 | ACS | Lawrie | Acquired via trade | SFR | | After |
| 2/2/2016 | ACS | Markakis | Traded away | SFR | | After |
| 2/2/2016 | ACS | Martin,L | Traded away | SFR | | After |
| 2/2/2016 | ACS | Ross,J | Traded away | SFR | | After |
| 2/2/2016 | ACS | Zimmermann | Traded away | FH | | After |
| 2/2/2016 | End | Montero,M | Acquired via trade | PL | | After |
| 2/2/2016 | FH | Bour | Traded away | ACS | | After |
| 2/2/2016 | FH | Zimmermann | Acquired via trade | ACS | | After |
| 2/2/2016 | HS | Lucroy | Traded away | WN | | After |
| 2/2/2016 | HS | Posey | Acquired via trade | WN | | After |
| 2/2/2016 | HS | Schwarber | Traded away | WN | | After |
| 2/2/2016 | PL | Montero,M | Traded away | End | | After |
| 2/2/2016 | SFR | Ackley | Traded away | ACS | | After |
| 2/2/2016 | SFR | Adams,M | Traded away | ACS | | After |
| 2/2/2016 | SFR | Alvarez,P | Traded away | ACS | | After |
| 2/2/2016 | SFR | Duffey | Acquired via trade | ACS | | After |
| 2/2/2016 | SFR | Gomes,Y | Traded away | ACS | | After |
| 2/2/2016 | SFR | Kela | Acquired via trade | ACS | | After |
| 2/2/2016 | SFR | Lawrie | Traded away | ACS | | After |
| 2/2/2016 | SFR | Markakis | Acquired via trade | ACS | | After |
| 2/2/2016 | SFR | Martin,L | Acquired via trade | ACS | | After |
| 2/2/2016 | SFR | Ross,J | Acquired via trade | ACS | | After |
| 2/2/2016 | WN | Lucroy | Acquired via trade | HS | | After |
| 2/2/2016 | WN | Posey | Traded away | HS | | After |
| 2/2/2016 | WN | Schwarber | Acquired via trade | HS | | After |
| 2/9/2016 | ACS | Strop | Traded away | VD | | After |
| 2/9/2016 | VD | Strop | Acquired via trade | ACS | | After |
| 2/10/2016 | End | Wilson,A | Traded away | PL | | After |
| 2/10/2016 | PL | Wilson,A | Acquired via trade | End | | After |
| 2/13/2016 | ACS | Andrus | Traded away | SS | | After |
| 2/13/2016 | ACS | Coghlan | Acquired via trade | SS | | After |
| 2/13/2016 | SS | Andrus | Acquired via trade | ACS | | After |
| 2/13/2016 | SS | Coghlan | Traded away | ACS | | After |
| 2/19/2016 | BB | Mauer | Demoted to reserve roster | | | Before |
| 2/19/2016 | BB | Odor | Demoted to reserve roster | | | Before |
| 2/19/2016 | BB | Sanchez,An | Demoted to reserve roster | | | Before |
| 2/19/2016 | BB | Sandoval | Demoted to reserve roster | | | Before |
| 2/19/2016 | BB | Tucker | Demoted to reserve roster | | | Before |
| 2/19/2016 | PL | Peterson,J | Demoted to reserve roster | | | Before |
| 2/19/2016 | PL | Souza | Demoted to reserve roster | | | Before |
| 2/19/2016 | WN | Gyorko | Demoted to reserve roster | | | Before |
| 2/19/2016 | WN | Iglesias,R | Demoted to reserve roster | | | Before |
| 2/19/2016 | WN | Lucroy | Demoted to reserve roster | | | Before |
| 2/20/2016 | VD | BrettPhillips | Released | | | Before |
| 2/20/2016 | VD | Dietrich | Demoted to reserve roster | | | Before |
| 2/20/2016 | VD | Eovaldi | Demoted to reserve roster | | | Before |
| 2/20/2016 | VD | Parra,G | Demoted to reserve roster | | | Before |
| 2/20/2016 | VD | Phillips | Demoted to reserve roster | | | Before |
| 2/20/2016 | VD | Taylor,M | Demoted to reserve roster | | | Before |
| 2/21/2016 | AH | Hamilton,J | Demoted to reserve roster | | | Before |
| 2/21/2016 | BC | Schebler | Demoted to reserve roster | | | Before |
| 2/21/2016 | FH | Crawford | Demoted to reserve roster | | | Before |
| 2/21/2016 | HS | Alford | Demoted to reserve roster | | | Before |
| 2/21/2016 | HS | Bell | Demoted to reserve roster | | | Before |
| 2/21/2016 | HS | Wainwright | Demoted to reserve roster | | | Before |
| 2/21/2016 | HS | Wright,D | Demoted to reserve roster | | | Before |
| 2/22/2016 | SFR | Mesoraco | Demoted to reserve roster | | | Before |
| 2/24/2016 | ShS | Burnett | Demoted to reserve roster | | | Before |
| 2/24/2016 | ShS | Wacha | Promoted to active roster | | | Before |
| 2/28/2016 | BB | Gomez,C | Traded away | SS | | After |
| 2/28/2016 | BB | Jackson,A | Acquired via trade | SS | | After |
| 2/28/2016 | End | Seager,C | Signed | | | Before |
| 2/28/2016 | End | Seager,C | Demoted to reserve roster | | | Before |
| 2/28/2016 | SS | Gomez,C | Acquired via trade | BB | | After |
| 2/28/2016 | SS | Jackson,A | Traded away | BB | | After |
| 3/2/2016 | End | Givens | Acquired via trade | SS | | After |
| 3/2/2016 | End | Hosmer | Traded away | SS | | After |
| 3/2/2016 | End | Lincecum | Traded away | SS | | After |
| 3/2/2016 | End | Ventura | Acquired via trade | SS | | After |
| 3/2/2016 | SS | Givens | Traded away | End | | After |
| 3/2/2016 | SS | Hosmer | Acquired via trade | End | | After |
| 3/2/2016 | SS | Lincecum | Acquired via trade | End | | After |
| 3/2/2016 | SS | Ventura | Traded away | End | | After |
| 3/3/2016 | SS | Lincecum | Demoted to reserve roster | | | Before |
| 3/8/2016 | VD | Dietrich | Promoted to active roster | | | Before |
| 3/9/2016 | ShS | Holland,G | Traded away | SS | | After |
| 3/9/2016 | ShS | Mondesi | Acquired via trade | SS | | After |
| 3/9/2016 | SS | Paxton | Promoted to active roster | | | Before |
| 3/9/2016 | SS | Holland,G | Acquired via trade | ShS | | After |
| 3/9/2016 | SS | Mondesi | Traded away | ShS | | After |
| 3/10/2016 | SS | Holland,G | Promoted to active roster | | | Before |
| 3/10/2016 | SS | Howard | Demoted to reserve roster | | | Before |
| 3/10/2016 | SS | Paxton | Demoted to reserve roster | | | Before |
| 3/15/2016 | ACS | Bauer | Acquired via trade | SS | | After |
| 3/15/2016 | ACS | Hammel | Traded away | SS | | After |
| 3/15/2016 | SS | Bauer | Traded away | ACS | | After |
| 3/15/2016 | SS | Hammel | Acquired via trade | ACS | | After |
| 3/16/2016 | ShS | Burnett | Promoted to active roster | | | Before |
| 3/16/2016 | ShS | Ramirez,E | Demoted to reserve roster | | | Before |
| 3/16/2016 | SS | Paxton | Promoted to active roster | | | Before |
| 3/22/2016 | SS | Howard | Promoted to active roster | | | Before |
| 3/22/2016 | SS | Paxton | Demoted to reserve roster | | | Before |
| 3/23/2016 | SFR | Travis | Signed | | | Before |
| 3/23/2016 | SFR | Travis | Demoted to reserve roster | | | Before |