| Transactions | ||||||
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/16/2013 | MSB | Bastardo | Released | Before | ||
| 3/16/2013 | MSB | Collins | Released | Before | ||
| 3/16/2013 | MSB | Kelly,J | Promoted to active roster | Before | ||
| 3/16/2013 | MSB | Rasmus | Promoted to active roster | Before | ||
| 3/16/2013 | ShS | Joyce | Promoted to active roster | Before | ||
| 3/18/2013 | ACS | Bruce | Acquired via trade | SS | After | |
| 3/18/2013 | ACS | d'Arnaud | Traded away | SS | After | |
| 3/18/2013 | ACS | Doumit | Acquired via trade | SS | After | |
| 3/18/2013 | ACS | Escobar,A | Acquired via trade | SS | After | |
| 3/18/2013 | ACS | Granderson | Traded away | End | After | |
| 3/18/2013 | ACS | Izturis,M | Traded away | SS | After | |
| 3/18/2013 | ACS | Jones,C | Acquired via trade | End | After | |
| 3/18/2013 | ACS | Profar | Traded away | MSB | After | |
| 3/18/2013 | ACS | Ruiz | Traded away | SS | After | |
| 3/18/2013 | End | Davis,I | Acquired via trade | ShS | After | |
| 3/18/2013 | End | Granderson | Acquired via trade | ACS | After | |
| 3/18/2013 | End | Jones,C | Traded away | ACS | After | |
| 3/18/2013 | End | Konerko | Traded away | ShS | After | |
| 3/18/2013 | MSB | Craig | Acquired via trade | BC | After | |
| 3/18/2013 | MSB | Eaton | Acquired via trade | SS | After | |
| 3/18/2013 | MSB | Kershaw | Traded away | BC | After | |
| 3/18/2013 | MSB | Lawrie | Acquired via trade | BC | After | |
| 3/18/2013 | MSB | Moreland | Traded away | BC | After | |
| 3/18/2013 | MSB | Murphy,DM | Traded away | SS | After | |
| 3/18/2013 | MSB | Profar | Acquired via trade | ACS | After | |
| 3/18/2013 | MSB | Wainwright | Acquired via trade | BC | After | |
| 3/18/2013 | ShS | Davis,I | Traded away | End | After | |
| 3/18/2013 | ShS | Davis,I | Acquired via trade | PP | After | |
| 3/18/2013 | ShS | Gregerson | Traded away | ATT | After | |
| 3/18/2013 | ShS | Joyce | Acquired via trade | ATT | After | |
| 3/18/2013 | ShS | Konerko | Acquired via trade | End | After | |
| 3/18/2013 | ShS | Price | Traded away | PP | After | |