| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 2/17/2011 | End | Crowe | Demoted to reserve roster | | | Before |
| 2/18/2011 | BC | Escobar,A | Traded away | SS | | After |
| 2/18/2011 | BC | Garland | Acquired via trade | SS | | After |
| 2/18/2011 | SS | Escobar,A | Acquired via trade | BC | | After |
| 2/18/2011 | SS | Garland | Traded away | BC | | After |
| 2/21/2011 | BC | Holland,D | Demoted to reserve roster | | | Before |
| 2/21/2011 | DMB | Boesch | Demoted to reserve roster | | | Before |
| 2/21/2011 | DMB | Contreras | Demoted to reserve roster | | | Before |
| 2/21/2011 | DMB | Cuddyer | Demoted to reserve roster | | | Before |
| 2/21/2011 | DMB | Desmond | Demoted to reserve roster | | | Before |
| 2/21/2011 | DMB | Torrealba | Demoted to reserve roster | | | Before |
| 2/21/2011 | SS | Escobar,A | Promoted to active roster | | | Before |
| 2/23/2011 | PL | Matsui,H | Signed | | | Before |
| 2/23/2011 | SFR | Hernandez,Li | Demoted to reserve roster | | | Before |
| 2/23/2011 | SFR | Lilly | Promoted to active roster | | | Before |
| 3/3/2011 | HS | Beltre,A | Demoted to reserve roster | | | Before |
| 3/3/2011 | HS | Freese | Promoted to active roster | | | Before |
| 3/5/2011 | SFR | Hernandez,Li | Promoted to active roster | | | Before |
| 3/5/2011 | SFR | Wheeler | Demoted to reserve roster | | | Before |
| 3/7/2011 | ShS | Boggs,M | Promoted to active roster | | | Before |
| 3/7/2011 | ShS | Hunter,Tom | Demoted to reserve roster | | | Before |
| 3/9/2011 | SFR | Peralta,Jh | Demoted to reserve roster | | | Before |
| 3/9/2011 | SFR | Stewart,I | Promoted to active roster | | | Before |
| 3/13/2011 | ShS | Hunter,Tom | Promoted to active roster | | | Before |
| 3/13/2011 | ShS | Pettitte | Placed on disabled list | | 3/11/2011 | Before |
| 3/17/2011 | SFR | Peralta,Jh | Promoted to active roster | | | Before |
| 3/17/2011 | SFR | Stewart,I | Demoted to reserve roster | | | Before |
| 3/19/2011 | WAP | Brantley | Demoted to reserve roster | | | Before |
| 3/19/2011 | WAP | Cordero,F | Demoted to reserve roster | | | Before |
| 3/19/2011 | WAP | Figueroa | Demoted to reserve roster | | | Before |
| 3/19/2011 | WAP | Jepsen | Demoted to reserve roster | | | Before |
| 3/19/2011 | WAP | Mahay | Demoted to reserve roster | | | Before |
| 3/19/2011 | WAP | Robertson,D | Demoted to reserve roster | | | Before |
| 3/19/2011 | WAP | Rodney | Demoted to reserve roster | | | Before |
| 3/19/2011 | WAP | Smith,Joe | Demoted to reserve roster | | | Before |
| 3/19/2011 | WAP | Ziegler | Demoted to reserve roster | | | Before |
| 3/20/2011 | ATT | Pagan | Traded away | ShS | | After |
| 3/20/2011 | ATT | Spilborghs | Acquired via trade | ShS | | After |
| 3/20/2011 | ShS | Pagan | Acquired via trade | ATT | | After |
| 3/20/2011 | ShS | Spilborghs | Traded away | ATT | | After |