Real-life pitching register -- All players in database
Regular season
| Primary |
| Name | Team | P | Age | ERA | W | L | S | G | GS | CG | SHO | INN | H | R | ER | BB | K | HR | GDP |
| Brett Anderson* | Oak | sp | 21 | 4.06 | 11 | 11 | 0 | 30 | 30 | 1 | 1 | 175.1 | 180 | 94 | 79 | 45 | 150 | 20 | 24 |
| Bronson Arroyo | Cin | sp | 32 | 3.84 | 15 | 13 | 0 | 33 | 33 | 3 | 2 | 220.1 | 214 | 101 | 94 | 65 | 127 | 31 | 24 |
| Homer Bailey | Cin | sp | 23 | 4.53 | 8 | 5 | 0 | 20 | 20 | 0 | 0 | 113.1 | 115 | 61 | 57 | 52 | 86 | 12 | 7 |
| Scott Baker | Min | sp | 27 | 4.36 | 15 | 9 | 0 | 33 | 33 | 1 | 1 | 200.0 | 190 | 99 | 97 | 48 | 162 | 28 | 10 |
| Brian Bannister | KC | sp | 28 | 4.73 | 7 | 12 | 0 | 26 | 26 | 0 | 0 | 154.0 | 161 | 94 | 81 | 50 | 98 | 15 | 12 |
| Josh Beckett | Bos | sp | 29 | 3.86 | 17 | 6 | 0 | 32 | 32 | 4 | 2 | 212.1 | 198 | 99 | 91 | 55 | 199 | 25 | 14 |
| Erik Bedard* | Sea | sp | 30 | 2.82 | 5 | 3 | 0 | 15 | 15 | 0 | 0 | 83.0 | 65 | 29 | 26 | 34 | 90 | 8 | 2 |
| Brad Bergesen | Bal | sp | 23 | 3.43 | 7 | 5 | 0 | 19 | 19 | 1 | 0 | 123.1 | 126 | 52 | 47 | 32 | 65 | 11 | 12 |
| Jason Berken | Bal | sp | 25 | 6.54 | 6 | 12 | 0 | 24 | 24 | 0 | 0 | 119.2 | 164 | 92 | 87 | 44 | 66 | 19 | 13 |
| Chad Billingsley | LAN | sp | 24 | 4.03 | 12 | 11 | 0 | 33 | 32 | 0 | 0 | 196.1 | 173 | 94 | 88 | 86 | 179 | 17 | 18 |
| Nick Blackburn | Min | sp | 27 | 4.03 | 11 | 11 | 0 | 33 | 33 | 3 | 0 | 205.2 | 240 | 103 | 92 | 41 | 98 | 25 | 14 |
| Joe Blanton | Phi | sp | 28 | 4.05 | 12 | 8 | 0 | 31 | 31 | 0 | 0 | 195.1 | 198 | 89 | 88 | 59 | 163 | 30 | 11 |
| Mitchell Boggs | StL | sp | 25 | 4.19 | 2 | 3 | 0 | 16 | 9 | 0 | 0 | 58.0 | 71 | 28 | 27 | 33 | 46 | 3 | 7 |
| Dallas Braden* | Oak | sp | 25 | 3.89 | 8 | 9 | 0 | 22 | 22 | 0 | 0 | 136.2 | 144 | 63 | 59 | 42 | 81 | 9 | 10 |
| Clay Buchholz | Bos | sp | 24 | 4.21 | 7 | 4 | 0 | 16 | 16 | 0 | 0 | 92.0 | 91 | 44 | 43 | 36 | 68 | 13 | 7 |
| Billy Buckner | Ari | sp | 25 | 6.40 | 4 | 6 | 0 | 16 | 13 | 0 | 0 | 77.1 | 94 | 57 | 55 | 29 | 64 | 12 | 13 |
| Mark Buehrle* | ChA | sp | 30 | 3.84 | 13 | 10 | 0 | 33 | 33 | 1 | 1 | 213.1 | 222 | 97 | 91 | 45 | 105 | 27 | 28 |
| A.J. Burnett | NYA | sp | 32 | 4.04 | 13 | 9 | 0 | 33 | 33 | 1 | 0 | 207.0 | 193 | 99 | 93 | 97 | 195 | 25 | 15 |
| Mike Burns | Mil | sp | 30 | 5.75 | 3 | 5 | 0 | 15 | 8 | 0 | 0 | 51.2 | 60 | 36 | 33 | 17 | 39 | 10 | 8 |
| Dave Bush | Mil | sp | 29 | 6.38 | 5 | 9 | 0 | 22 | 21 | 0 | 0 | 114.1 | 131 | 84 | 81 | 37 | 89 | 19 | 9 |
| Daniel Cabrera |   | sp | 28 | 6.00 | 0 | 6 | 0 | 15 | 9 | 0 | 0 | 51.0 | 59 | 47 | 34 | 42 | 23 | 4 | 8 |
| Trevor Cahill | Oak | sp | 21 | 4.63 | 10 | 13 | 0 | 32 | 32 | 0 | 0 | 178.2 | 185 | 99 | 92 | 72 | 90 | 27 | 18 |
| Matt Cain | SF | sp | 24 | 2.89 | 14 | 8 | 0 | 33 | 33 | 4 | 0 | 217.2 | 184 | 73 | 70 | 73 | 171 | 22 | 14 |
| Fausto Carmona | Cle | sp | 25 | 6.32 | 5 | 12 | 0 | 24 | 24 | 0 | 0 | 125.1 | 151 | 97 | 88 | 70 | 79 | 16 | 10 |
| Chris Carpenter | StL | sp | 34 | 2.24 | 17 | 4 | 0 | 28 | 28 | 3 | 1 | 192.2 | 156 | 49 | 48 | 38 | 144 | 7 | 23 |
| Brett Cecil* | Tor | sp | 22 | 5.30 | 7 | 4 | 0 | 18 | 17 | 0 | 0 | 93.1 | 116 | 59 | 55 | 38 | 69 | 17 | 10 |
| Joba Chamberlain | NYA | sp | 23 | 4.75 | 9 | 6 | 0 | 32 | 31 | 0 | 0 | 157.1 | 167 | 94 | 83 | 76 | 133 | 21 | 13 |
| Bruce Chen* | KC | sp | 32 | 5.78 | 1 | 6 | 0 | 17 | 9 | 0 | 0 | 62.1 | 74 | 42 | 40 | 25 | 45 | 12 | 4 |
| Bartolo Colon | ChA | sp | 36 | 4.19 | 3 | 6 | 0 | 12 | 12 | 0 | 0 | 62.1 | 69 | 42 | 29 | 21 | 38 | 13 | 3 |
| Jose Contreras |   | sp | 37 | 4.92 | 6 | 13 | 0 | 28 | 23 | 0 | 0 | 131.2 | 141 | 86 | 72 | 53 | 106 | 13 | 11 |
| Aaron Cook | Col | sp | 30 | 4.16 | 11 | 6 | 0 | 27 | 27 | 1 | 1 | 158.0 | 175 | 76 | 73 | 47 | 78 | 19 | 19 |
| Kevin Correia | SD | sp | 28 | 3.91 | 12 | 11 | 0 | 33 | 33 | 1 | 1 | 198.0 | 194 | 92 | 86 | 64 | 142 | 17 | 14 |
| Johnny Cueto | Cin | sp | 23 | 4.41 | 11 | 11 | 0 | 30 | 30 | 0 | 0 | 171.1 | 172 | 90 | 84 | 61 | 132 | 24 | 15 |
| John Danks* | ChA | sp | 24 | 3.77 | 13 | 11 | 0 | 32 | 32 | 1 | 0 | 200.1 | 184 | 89 | 84 | 73 | 149 | 28 | 22 |
| Kyle Davies | KC | sp | 25 | 5.27 | 8 | 9 | 0 | 22 | 22 | 1 | 0 | 123.0 | 122 | 76 | 72 | 66 | 86 | 18 | 13 |
| Doug Davis* | Ari | sp | 33 | 4.12 | 9 | 14 | 0 | 34 | 34 | 0 | 0 | 203.1 | 203 | 101 | 93 | 103 | 146 | 25 | 20 |
| Jorge de la Rosa* | Col | sp | 28 | 4.38 | 16 | 9 | 0 | 33 | 32 | 0 | 0 | 185.0 | 172 | 95 | 90 | 83 | 193 | 20 | 11 |
| Ryan Dempster | ChN | sp | 32 | 3.64 | 11 | 9 | 0 | 31 | 31 | 1 | 1 | 200.0 | 196 | 94 | 81 | 65 | 172 | 22 | 17 |
| Ross Detwiler* | Was | sp | 23 | 5.00 | 1 | 6 | 0 | 15 | 14 | 1 | 0 | 75.2 | 87 | 43 | 42 | 33 | 43 | 3 | 9 |
| Zach Duke* | Pit | sp | 26 | 4.06 | 11 | 16 | 0 | 32 | 32 | 3 | 1 | 213.0 | 231 | 101 | 96 | 49 | 106 | 23 | 20 |
| Adam Eaton |   | sp | 31 | 8.08 | 3 | 5 | 0 | 12 | 8 | 0 | 0 | 49.0 | 65 | 44 | 44 | 27 | 35 | 10 | 3 |
| Dana Eveland* | Oak | sp | 25 | 7.16 | 2 | 4 | 0 | 13 | 9 | 0 | 0 | 44.0 | 70 | 39 | 35 | 26 | 22 | 4 | 8 |
| Scott Feldman | Tex | sp | 26 | 4.08 | 17 | 8 | 0 | 34 | 31 | 0 | 0 | 189.2 | 178 | 87 | 86 | 65 | 113 | 18 | 21 |
| Nelson Figueroa | NYN | sp | 35 | 4.09 | 3 | 8 | 0 | 16 | 10 | 1 | 1 | 70.1 | 80 | 33 | 32 | 24 | 59 | 8 | 3 |
| Doug Fister | Sea | sp | 25 | 4.13 | 3 | 4 | 0 | 11 | 10 | 0 | 0 | 61.0 | 63 | 29 | 28 | 15 | 36 | 11 | 7 |
| Gavin Floyd | ChA | sp | 26 | 4.06 | 11 | 11 | 0 | 30 | 30 | 1 | 0 | 193.0 | 178 | 93 | 87 | 59 | 163 | 21 | 21 |
| Lucas French* |   | sp | 23 | 5.21 | 4 | 5 | 0 | 15 | 12 | 0 | 0 | 67.1 | 87 | 45 | 39 | 28 | 42 | 11 | 4 |
| Armando Galarraga | Det | sp | 27 | 5.64 | 6 | 10 | 0 | 29 | 25 | 0 | 0 | 143.2 | 158 | 93 | 90 | 67 | 95 | 24 | 12 |
| Yovani Gallardo | Mil | sp | 23 | 3.73 | 13 | 12 | 0 | 30 | 30 | 1 | 0 | 185.2 | 150 | 78 | 77 | 94 | 204 | 21 | 11 |
| Freddy Garcia | ChA | sp | 33 | 4.34 | 3 | 4 | 0 | 9 | 9 | 0 | 0 | 56.0 | 56 | 27 | 27 | 12 | 37 | 4 | 5 |
| Jon Garland |   | sp | 29 | 4.01 | 11 | 13 | 0 | 33 | 33 | 1 | 0 | 204.0 | 225 | 106 | 91 | 61 | 109 | 23 | 25 |
| Matt Garza | Tam | sp | 25 | 3.95 | 8 | 12 | 0 | 32 | 32 | 0 | 0 | 203.0 | 177 | 93 | 89 | 79 | 189 | 25 | 14 |
| Chad Gaudin |   | sp | 26 | 4.64 | 6 | 10 | 0 | 31 | 25 | 0 | 0 | 147.1 | 146 | 85 | 76 | 76 | 139 | 14 | 8 |
| Josh Geer | SD | sp | 26 | 5.96 | 1 | 7 | 0 | 19 | 17 | 0 | 0 | 102.2 | 116 | 73 | 68 | 23 | 54 | 27 | 8 |
| Gio Gonzalez* | Oak | sp | 23 | 5.75 | 6 | 7 | 0 | 20 | 17 | 0 | 0 | 98.2 | 113 | 68 | 63 | 56 | 109 | 14 | 10 |
| Zack Greinke | KC | sp | 25 | 2.16 | 16 | 8 | 0 | 33 | 33 | 6 | 3 | 229.1 | 195 | 64 | 55 | 51 | 242 | 11 | 17 |
| Jeremy Guthrie | Bal | sp | 30 | 5.04 | 10 | 17 | 0 | 33 | 33 | 1 | 0 | 200.0 | 224 | 120 | 112 | 60 | 110 | 35 | 17 |
| Roy Halladay | Tor | sp | 32 | 2.79 | 17 | 10 | 0 | 32 | 32 | 9 | 4 | 239.0 | 234 | 82 | 74 | 35 | 208 | 22 | 21 |
| Cole Hamels* | Phi | sp | 25 | 4.32 | 10 | 11 | 0 | 32 | 32 | 2 | 2 | 193.2 | 206 | 95 | 93 | 43 | 168 | 24 | 11 |
| Jason Hammel | Col | sp | 26 | 4.33 | 10 | 8 | 0 | 34 | 30 | 1 | 0 | 176.2 | 203 | 94 | 85 | 42 | 133 | 17 | 9 |
| Mike Hampton* | Hou | sp | 36 | 5.30 | 7 | 10 | 0 | 21 | 21 | 0 | 0 | 112.0 | 128 | 71 | 66 | 46 | 74 | 13 | 13 |
| Tommy Hanson | Atl | sp | 22 | 2.89 | 11 | 4 | 0 | 21 | 21 | 0 | 0 | 127.2 | 105 | 42 | 41 | 46 | 116 | 10 | 13 |
| J.A. Happ* | Phi | sp | 26 | 2.93 | 12 | 4 | 0 | 35 | 23 | 3 | 2 | 166.0 | 149 | 55 | 54 | 56 | 119 | 20 | 16 |
| Aaron Harang | Cin | sp | 31 | 4.21 | 6 | 14 | 0 | 26 | 26 | 2 | 1 | 162.1 | 186 | 82 | 76 | 43 | 142 | 24 | 11 |
| Rich Harden | ChN | sp | 27 | 4.09 | 9 | 9 | 0 | 26 | 26 | 0 | 0 | 141.0 | 122 | 74 | 64 | 67 | 171 | 23 | 9 |
| Dan Haren | Ari | sp | 28 | 3.14 | 14 | 10 | 0 | 33 | 33 | 3 | 1 | 229.1 | 192 | 83 | 80 | 38 | 223 | 27 | 12 |
| Matt Harrison* | Tex | sp | 23 | 6.11 | 4 | 5 | 0 | 11 | 11 | 2 | 1 | 63.1 | 81 | 43 | 43 | 23 | 34 | 9 | 8 |
| Kevin Hart |   | sp | 26 | 5.44 | 4 | 9 | 0 | 18 | 14 | 0 | 0 | 81.0 | 97 | 55 | 49 | 44 | 52 | 11 | 13 |
| David Hernandez | Bal | sp | 24 | 5.42 | 4 | 10 | 0 | 20 | 19 | 0 | 0 | 101.1 | 118 | 62 | 61 | 46 | 68 | 27 | 5 |
| Felix Hernandez | Sea | sp | 23 | 2.49 | 19 | 5 | 0 | 34 | 34 | 2 | 1 | 238.2 | 200 | 81 | 66 | 71 | 217 | 15 | 20 |
| Livan Hernandez |   | sp | 34 | 5.44 | 9 | 12 | 0 | 31 | 31 | 2 | 0 | 183.2 | 220 | 112 | 111 | 67 | 102 | 19 | 24 |
| Rich Hill* | Bal | sp | 29 | 7.80 | 3 | 3 | 0 | 14 | 13 | 0 | 0 | 57.2 | 68 | 53 | 50 | 40 | 46 | 7 | 5 |
| Luke Hochevar | KC | sp | 25 | 6.55 | 7 | 13 | 0 | 25 | 25 | 2 | 1 | 143.0 | 167 | 109 | 104 | 46 | 106 | 23 | 16 |
| Derek Holland* | Tex | sp | 22 | 6.12 | 8 | 13 | 0 | 33 | 21 | 1 | 1 | 138.1 | 160 | 98 | 94 | 47 | 107 | 26 | 13 |
| Tim Hudson | Atl | sp | 33 | 3.61 | 2 | 1 | 0 | 7 | 7 | 0 | 0 | 42.1 | 49 | 17 | 17 | 13 | 30 | 4 | 5 |
| David Huff* | Cle | sp | 24 | 5.61 | 11 | 8 | 0 | 23 | 23 | 0 | 0 | 128.1 | 159 | 82 | 80 | 41 | 65 | 16 | 13 |
| Tommy Hunter | Tex | sp | 22 | 4.10 | 9 | 6 | 0 | 19 | 19 | 1 | 0 | 112.0 | 113 | 55 | 51 | 33 | 64 | 13 | 9 |
| Edwin Jackson | Det | sp | 25 | 3.62 | 13 | 9 | 0 | 33 | 33 | 1 | 0 | 214.0 | 200 | 93 | 86 | 70 | 161 | 27 | 17 |
| Ubaldo Jimenez | Col | sp | 25 | 3.47 | 15 | 12 | 0 | 33 | 33 | 1 | 0 | 218.0 | 183 | 87 | 84 | 85 | 198 | 13 | 15 |
| Josh Johnson | Flo | sp | 25 | 3.23 | 15 | 5 | 0 | 33 | 33 | 2 | 0 | 209.0 | 184 | 77 | 75 | 58 | 191 | 14 | 17 |
| Randy Johnson* | SF | sp | 45 | 4.88 | 8 | 6 | 0 | 22 | 17 | 0 | 0 | 96.0 | 97 | 55 | 52 | 31 | 86 | 19 | 8 |
| Jair Jurrjens | Atl | sp | 23 | 2.60 | 14 | 10 | 0 | 34 | 34 | 0 | 0 | 215.0 | 186 | 71 | 62 | 75 | 152 | 15 | 16 |
| Kenshin Kawakami | Atl | sp | 34 | 3.86 | 7 | 12 | 1 | 32 | 25 | 0 | 0 | 156.1 | 153 | 73 | 67 | 57 | 105 | 15 | 12 |
| Scott Kazmir* |   | sp | 25 | 4.89 | 10 | 9 | 0 | 26 | 26 | 0 | 0 | 147.1 | 149 | 85 | 80 | 60 | 117 | 16 | 12 |
| Clayton Kershaw* | LAN | sp | 21 | 2.79 | 8 | 8 | 0 | 31 | 30 | 0 | 0 | 171.0 | 119 | 55 | 53 | 91 | 185 | 7 | 12 |
| Hiroki Kuroda | LAN | sp | 34 | 3.76 | 8 | 7 | 0 | 21 | 20 | 0 | 0 | 117.1 | 110 | 59 | 49 | 24 | 87 | 12 | 8 |
| John Lackey | LAA | sp | 30 | 3.83 | 11 | 8 | 0 | 27 | 27 | 1 | 1 | 176.1 | 177 | 84 | 75 | 47 | 139 | 17 | 17 |
| Aaron Laffey* | Cle | sp | 24 | 4.44 | 7 | 9 | 1 | 25 | 19 | 0 | 0 | 121.2 | 140 | 69 | 60 | 57 | 59 | 9 | 26 |
| John Lannan* | Was | sp | 24 | 3.88 | 9 | 13 | 0 | 33 | 33 | 2 | 1 | 206.1 | 210 | 100 | 89 | 68 | 89 | 22 | 28 |
| Mat Latos | SD | sp | 21 | 4.62 | 4 | 5 | 0 | 10 | 10 | 0 | 0 | 50.2 | 43 | 29 | 26 | 23 | 39 | 7 | 3 |
| Wade LeBlanc* | SD | sp | 24 | 3.69 | 3 | 1 | 0 | 9 | 9 | 0 | 0 | 46.1 | 35 | 19 | 19 | 19 | 30 | 6 | 3 |
| Cliff Lee* |   | sp | 30 | 3.22 | 14 | 13 | 0 | 34 | 34 | 6 | 2 | 231.2 | 245 | 88 | 83 | 43 | 181 | 17 | 14 |
| Justin Lehr | Cin | sp | 31 | 5.37 | 5 | 3 | 0 | 11 | 11 | 1 | 1 | 65.1 | 72 | 39 | 39 | 28 | 33 | 14 | 5 |
| Jon Lester* | Bos | sp | 25 | 3.41 | 15 | 8 | 0 | 32 | 32 | 2 | 0 | 203.1 | 186 | 80 | 77 | 64 | 225 | 20 | 14 |
| Ted Lilly* | ChN | sp | 33 | 3.10 | 12 | 9 | 0 | 27 | 27 | 0 | 0 | 177.0 | 151 | 66 | 61 | 36 | 151 | 22 | 14 |
| Tim Lincecum | SF | sp | 25 | 2.48 | 15 | 7 | 0 | 32 | 32 | 4 | 2 | 225.1 | 168 | 69 | 62 | 68 | 261 | 10 | 9 |
| Francisco Liriano* | Min | sp | 25 | 5.80 | 5 | 13 | 0 | 29 | 24 | 0 | 0 | 136.2 | 147 | 93 | 88 | 65 | 122 | 21 | 11 |
| Kyle Lohse | StL | sp | 30 | 4.74 | 6 | 10 | 0 | 23 | 22 | 1 | 1 | 117.2 | 125 | 69 | 62 | 36 | 77 | 16 | 6 |
| Braden Looper | Mil | sp | 34 | 5.22 | 14 | 7 | 0 | 34 | 34 | 0 | 0 | 194.2 | 226 | 123 | 113 | 64 | 100 | 39 | 19 |
| Derek Lowe | Atl | sp | 36 | 4.67 | 15 | 10 | 0 | 34 | 34 | 0 | 0 | 194.2 | 232 | 109 | 101 | 63 | 111 | 16 | 28 |
| Paul Maholm* | Pit | sp | 27 | 4.44 | 8 | 9 | 0 | 31 | 31 | 0 | 0 | 194.2 | 221 | 102 | 96 | 60 | 119 | 14 | 28 |
| John Maine | NYN | sp | 28 | 4.43 | 7 | 6 | 0 | 15 | 15 | 0 | 0 | 81.1 | 67 | 42 | 40 | 38 | 55 | 8 | 2 |
| Jason Marquis | Col | sp | 30 | 4.04 | 15 | 13 | 0 | 33 | 33 | 2 | 1 | 216.0 | 218 | 104 | 97 | 80 | 115 | 15 | 28 |
| J.D. Martin | Was | sp | 26 | 4.44 | 5 | 4 | 0 | 15 | 15 | 0 | 0 | 77.0 | 85 | 40 | 38 | 24 | 37 | 14 | 3 |
| Pedro Martinez | Phi | sp | 37 | 3.63 | 5 | 1 | 0 | 9 | 9 | 0 | 0 | 44.2 | 48 | 18 | 18 | 8 | 37 | 7 | 1 |
| Shairon Martis | Was | sp | 22 | 5.25 | 5 | 3 | 0 | 15 | 15 | 1 | 0 | 85.2 | 83 | 52 | 50 | 39 | 34 | 11 | 5 |
| Daisuke Matsuzaka | Bos | sp | 28 | 5.76 | 4 | 6 | 0 | 12 | 12 | 0 | 0 | 59.1 | 81 | 38 | 38 | 30 | 54 | 10 | 4 |
| Brian Matusz* | Bal | sp | 22 | 4.63 | 5 | 2 | 0 | 8 | 8 | 0 | 0 | 44.2 | 52 | 24 | 23 | 14 | 38 | 6 | 3 |
| Vin Mazzaro | Oak | sp | 22 | 5.32 | 4 | 9 | 0 | 17 | 17 | 0 | 0 | 91.1 | 120 | 61 | 54 | 39 | 59 | 12 | 7 |
| Brandon McCarthy | Tex | sp | 25 | 4.62 | 7 | 4 | 0 | 17 | 17 | 1 | 1 | 97.1 | 96 | 55 | 50 | 36 | 65 | 13 | 5 |
| Gil Meche | KC | sp | 30 | 5.09 | 6 | 10 | 0 | 23 | 23 | 1 | 1 | 129.0 | 144 | 81 | 73 | 58 | 95 | 17 | 13 |
| Andrew Miller* | Flo | sp | 24 | 4.84 | 3 | 5 | 0 | 20 | 14 | 0 | 0 | 80.0 | 85 | 52 | 43 | 43 | 59 | 7 | 6 |
| Kevin Millwood | Tex | sp | 34 | 3.67 | 13 | 10 | 0 | 31 | 31 | 3 | 0 | 198.2 | 195 | 88 | 81 | 71 | 123 | 26 | 19 |
| Sergio Mitre | NYA | sp | 28 | 6.79 | 3 | 3 | 0 | 12 | 9 | 0 | 0 | 51.2 | 71 | 45 | 39 | 13 | 32 | 10 | 6 |
| Garrett Mock | Was | sp | 26 | 5.62 | 3 | 10 | 0 | 28 | 15 | 0 | 0 | 91.1 | 114 | 65 | 57 | 44 | 72 | 9 | 11 |
| Brian Moehler | Hou | sp | 37 | 5.47 | 8 | 12 | 0 | 29 | 29 | 1 | 0 | 154.2 | 187 | 101 | 94 | 51 | 91 | 21 | 16 |
| Charlie Morton | Pit | sp | 25 | 4.55 | 5 | 9 | 0 | 18 | 18 | 1 | 1 | 97.0 | 102 | 49 | 49 | 40 | 62 | 7 | 13 |
| Jamie Moyer* | Phi | sp | 46 | 4.94 | 12 | 10 | 0 | 30 | 25 | 0 | 0 | 162.0 | 177 | 91 | 89 | 43 | 94 | 27 | 10 |
| Brett Myers | Phi | sp | 28 | 4.84 | 4 | 3 | 0 | 18 | 10 | 0 | 0 | 70.2 | 74 | 38 | 38 | 23 | 50 | 18 | 5 |
| Jeff Niemann | Tam | sp | 26 | 3.94 | 13 | 6 | 0 | 31 | 30 | 2 | 2 | 180.2 | 185 | 84 | 79 | 59 | 125 | 17 | 19 |
| Dustin Nippert | Tex | sp | 28 | 3.88 | 5 | 3 | 0 | 20 | 10 | 0 | 0 | 69.2 | 64 | 31 | 30 | 29 | 54 | 7 | 6 |
| Ricky Nolasco | Flo | sp | 26 | 5.06 | 13 | 9 | 0 | 31 | 31 | 2 | 0 | 185.0 | 188 | 111 | 104 | 44 | 195 | 23 | 7 |
| Bud Norris | Hou | sp | 24 | 4.53 | 6 | 3 | 0 | 11 | 10 | 0 | 0 | 55.2 | 59 | 29 | 28 | 25 | 54 | 9 | 4 |
| Sean O'Sullivan | LAA | sp | 21 | 5.92 | 4 | 2 | 0 | 12 | 10 | 0 | 0 | 51.2 | 60 | 34 | 34 | 16 | 29 | 12 | 7 |
| Ross Ohlendorf | Pit | sp | 26 | 3.92 | 11 | 10 | 0 | 29 | 29 | 0 | 0 | 176.2 | 165 | 80 | 77 | 53 | 109 | 25 | 16 |
| Scott Olsen* | Was | sp | 25 | 6.03 | 2 | 4 | 0 | 11 | 11 | 0 | 0 | 62.2 | 83 | 45 | 42 | 25 | 42 | 11 | 5 |
| Russ Ortiz | Hou | sp | 35 | 5.57 | 3 | 6 | 0 | 23 | 13 | 0 | 0 | 85.2 | 95 | 56 | 53 | 48 | 65 | 8 | 12 |
| Roy Oswalt | Hou | sp | 31 | 4.12 | 8 | 6 | 0 | 30 | 30 | 3 | 0 | 181.1 | 183 | 83 | 83 | 42 | 138 | 19 | 18 |
| Josh Outman* | Oak | sp | 24 | 3.48 | 4 | 1 | 0 | 14 | 12 | 0 | 0 | 67.1 | 53 | 30 | 26 | 25 | 53 | 9 | 6 |
| Micah Owings | Cin | sp | 26 | 5.34 | 7 | 12 | 1 | 26 | 19 | 0 | 0 | 119.2 | 126 | 75 | 71 | 64 | 68 | 18 | 12 |
| Vicente Padilla |   | sp | 31 | 4.46 | 12 | 6 | 0 | 26 | 25 | 0 | 0 | 147.1 | 156 | 76 | 73 | 54 | 97 | 16 | 19 |
| Manny Parra* | Mil | sp | 26 | 6.36 | 11 | 11 | 0 | 27 | 27 | 0 | 0 | 140.0 | 179 | 108 | 99 | 77 | 116 | 19 | 14 |
| Felipe Paulino | Hou | sp | 25 | 6.27 | 3 | 11 | 0 | 23 | 17 | 0 | 0 | 97.2 | 126 | 73 | 68 | 37 | 93 | 20 | 8 |
| Carl Pavano |   | sp | 33 | 5.10 | 14 | 12 | 0 | 33 | 33 | 1 | 1 | 199.1 | 235 | 119 | 113 | 39 | 147 | 26 | 19 |
| Jake Peavy |   | sp | 28 | 3.45 | 9 | 6 | 0 | 16 | 16 | 1 | 0 | 101.2 | 80 | 41 | 39 | 34 | 110 | 8 | 8 |
| Mike Pelfrey | NYN | sp | 25 | 5.03 | 10 | 12 | 0 | 31 | 31 | 0 | 0 | 184.1 | 213 | 112 | 103 | 66 | 107 | 18 | 15 |
| Brad Penny |   | sp | 31 | 4.88 | 11 | 9 | 0 | 30 | 30 | 1 | 0 | 173.1 | 191 | 102 | 94 | 51 | 109 | 22 | 14 |
| Oliver Perez* | NYN | sp | 27 | 6.82 | 3 | 4 | 0 | 14 | 14 | 0 | 0 | 66.0 | 69 | 51 | 50 | 58 | 62 | 12 | 3 |
| Glen Perkins* | Min | sp | 26 | 5.89 | 6 | 7 | 0 | 18 | 17 | 0 | 0 | 96.1 | 120 | 64 | 63 | 23 | 45 | 13 | 10 |
| Yusmeiro Petit | Ari | sp | 24 | 5.82 | 3 | 10 | 0 | 23 | 17 | 0 | 0 | 89.2 | 102 | 62 | 58 | 34 | 74 | 19 | 2 |
| Andy Pettitte* | NYA | sp | 37 | 4.16 | 14 | 8 | 0 | 32 | 32 | 0 | 0 | 194.2 | 193 | 101 | 90 | 76 | 148 | 20 | 16 |
| Joel Pineiro | StL | sp | 30 | 3.49 | 15 | 12 | 0 | 32 | 32 | 3 | 2 | 214.0 | 218 | 94 | 83 | 27 | 105 | 11 | 29 |
| Sidney Ponson | KC | sp | 32 | 7.36 | 1 | 7 | 0 | 14 | 9 | 0 | 0 | 58.2 | 79 | 50 | 48 | 25 | 32 | 6 | 6 |
| Rick Porcello | Det | sp | 20 | 3.96 | 14 | 9 | 0 | 31 | 31 | 0 | 0 | 170.2 | 176 | 81 | 75 | 52 | 89 | 23 | 24 |
| David Price* | Tam | sp | 23 | 4.42 | 10 | 7 | 0 | 23 | 23 | 0 | 0 | 128.1 | 119 | 72 | 63 | 54 | 102 | 17 | 2 |
| David Purcey* | Tor | sp | 27 | 6.19 | 1 | 3 | 0 | 9 | 9 | 0 | 0 | 48.0 | 54 | 35 | 33 | 30 | 39 | 6 | 3 |
| Tim Redding | NYN | sp | 31 | 5.10 | 3 | 6 | 0 | 30 | 17 | 0 | 0 | 120.0 | 122 | 72 | 68 | 50 | 76 | 18 | 12 |
| Clayton Richard* |   | sp | 25 | 4.41 | 9 | 5 | 0 | 38 | 26 | 1 | 0 | 153.0 | 154 | 81 | 75 | 71 | 114 | 17 | 19 |
| Scott Richmond | Tor | sp | 29 | 5.52 | 8 | 11 | 0 | 27 | 24 | 1 | 0 | 138.2 | 147 | 90 | 85 | 59 | 117 | 27 | 7 |
| Wandy Rodriguez* | Hou | sp | 30 | 3.02 | 14 | 12 | 0 | 33 | 33 | 1 | 1 | 205.2 | 192 | 77 | 69 | 63 | 193 | 21 | 24 |
| Ricky Romero* | Tor | sp | 24 | 4.30 | 13 | 9 | 0 | 29 | 29 | 0 | 0 | 178.0 | 192 | 88 | 85 | 79 | 141 | 18 | 30 |
| Ryan Rowland-Smith* | Sea | sp | 26 | 3.74 | 5 | 4 | 0 | 15 | 15 | 0 | 0 | 96.1 | 87 | 43 | 40 | 27 | 52 | 9 | 7 |
| Marc Rzepczynski* | Tor | sp | 23 | 3.67 | 2 | 4 | 0 | 11 | 11 | 0 | 0 | 61.1 | 51 | 27 | 25 | 30 | 60 | 7 | 7 |
| C.C. Sabathia* | NYA | sp | 28 | 3.37 | 19 | 8 | 0 | 34 | 34 | 2 | 1 | 230.0 | 197 | 96 | 86 | 67 | 197 | 18 | 22 |
| Anibal Sanchez | Flo | sp | 25 | 3.87 | 4 | 8 | 0 | 16 | 16 | 0 | 0 | 86.0 | 84 | 39 | 37 | 46 | 71 | 10 | 8 |
| Jonathan Sanchez* | SF | sp | 26 | 4.24 | 8 | 12 | 0 | 32 | 29 | 1 | 1 | 163.1 | 135 | 82 | 77 | 88 | 177 | 19 | 9 |
| Ervin Santana | LAA | sp | 26 | 5.03 | 8 | 8 | 0 | 24 | 23 | 2 | 2 | 139.2 | 159 | 83 | 78 | 47 | 107 | 24 | 19 |
| Johan Santana* | NYN | sp | 30 | 3.13 | 13 | 9 | 0 | 25 | 25 | 0 | 0 | 166.2 | 156 | 67 | 58 | 46 | 146 | 20 | 8 |
| Joe Saunders* | LAA | sp | 28 | 4.60 | 16 | 7 | 0 | 31 | 31 | 1 | 1 | 186.0 | 202 | 102 | 95 | 64 | 101 | 29 | 27 |
| Max Scherzer | Ari | sp | 24 | 4.12 | 9 | 11 | 0 | 30 | 30 | 0 | 0 | 170.1 | 166 | 94 | 78 | 63 | 174 | 20 | 8 |
| James Shields | Tam | sp | 27 | 4.14 | 11 | 12 | 0 | 33 | 33 | 0 | 0 | 219.2 | 239 | 113 | 101 | 52 | 167 | 29 | 19 |
| Kevin Slowey | Min | sp | 25 | 4.86 | 10 | 3 | 0 | 16 | 16 | 0 | 0 | 90.2 | 113 | 50 | 49 | 15 | 75 | 15 | 6 |
| John Smoltz |   | sp | 42 | 6.35 | 3 | 8 | 0 | 15 | 15 | 0 | 0 | 78.0 | 95 | 55 | 55 | 18 | 73 | 11 | 5 |
| Ian Snell |   | sp | 27 | 4.84 | 7 | 10 | 0 | 27 | 27 | 1 | 0 | 145.0 | 148 | 82 | 78 | 83 | 89 | 14 | 13 |
| Andy Sonnanstine | Tam | sp | 26 | 6.77 | 6 | 9 | 0 | 22 | 18 | 0 | 0 | 99.2 | 131 | 85 | 75 | 34 | 60 | 19 | 9 |
| Jeremy Sowers* | Cle | sp | 26 | 5.25 | 6 | 11 | 0 | 23 | 22 | 0 | 0 | 123.1 | 134 | 73 | 72 | 52 | 51 | 11 | 12 |
| Craig Stammen | Was | sp | 25 | 5.11 | 4 | 7 | 0 | 19 | 19 | 1 | 0 | 105.2 | 112 | 67 | 60 | 24 | 48 | 14 | 4 |
| Tim Stauffer | SD | sp | 27 | 3.58 | 4 | 7 | 0 | 14 | 14 | 0 | 0 | 73.0 | 71 | 31 | 29 | 34 | 53 | 8 | 11 |
| Eric Stults* | LAN | sp | 29 | 4.86 | 4 | 3 | 0 | 10 | 10 | 1 | 1 | 50.0 | 51 | 27 | 27 | 26 | 33 | 3 | 5 |
| Jeff Suppan | Mil | sp | 34 | 5.29 | 7 | 12 | 0 | 30 | 30 | 0 | 0 | 161.2 | 200 | 106 | 95 | 74 | 80 | 25 | 22 |
| Anthony Swarzak | Min | sp | 23 | 6.25 | 3 | 7 | 0 | 12 | 12 | 0 | 0 | 59.0 | 76 | 43 | 41 | 20 | 34 | 12 | 7 |
| Brian Tallet* | Tor | sp | 31 | 5.32 | 7 | 9 | 0 | 37 | 25 | 0 | 0 | 160.2 | 169 | 99 | 95 | 72 | 120 | 20 | 10 |
| Chris Tillman | Bal | sp | 21 | 5.40 | 2 | 5 | 0 | 12 | 12 | 0 | 0 | 65.0 | 77 | 40 | 39 | 24 | 39 | 15 | 6 |
| Koji Uehara | Bal | sp | 34 | 4.05 | 2 | 4 | 0 | 12 | 12 | 0 | 0 | 66.2 | 71 | 33 | 30 | 12 | 48 | 7 | 4 |
| Rick VandenHurk | Flo | sp | 24 | 4.30 | 3 | 2 | 0 | 11 | 11 | 0 | 0 | 58.2 | 57 | 29 | 28 | 21 | 49 | 11 | 1 |
| Jason Vargas* | Sea | sp | 26 | 4.91 | 3 | 6 | 0 | 23 | 14 | 0 | 0 | 91.2 | 98 | 53 | 50 | 24 | 54 | 16 | 11 |
| Virgil Vasquez | Pit | sp | 27 | 5.84 | 2 | 5 | 0 | 14 | 7 | 0 | 0 | 44.2 | 58 | 30 | 29 | 18 | 29 | 6 | 4 |
| Javier Vazquez | Atl | sp | 32 | 2.87 | 15 | 10 | 0 | 32 | 32 | 3 | 0 | 219.1 | 181 | 75 | 70 | 44 | 238 | 20 | 10 |
| Justin Verlander | Det | sp | 26 | 3.45 | 19 | 9 | 0 | 35 | 35 | 3 | 1 | 240.0 | 219 | 99 | 92 | 63 | 269 | 20 | 10 |
| Edinson Volquez | Cin | sp | 25 | 4.35 | 4 | 2 | 0 | 9 | 9 | 0 | 0 | 49.2 | 34 | 25 | 24 | 32 | 47 | 6 | 2 |
| Chris Volstad | Flo | sp | 22 | 5.21 | 9 | 13 | 0 | 29 | 29 | 1 | 1 | 159.0 | 169 | 100 | 92 | 59 | 107 | 29 | 18 |
| Adam Wainwright | StL | sp | 27 | 2.63 | 19 | 8 | 0 | 34 | 34 | 1 | 0 | 233.0 | 216 | 75 | 68 | 66 | 212 | 17 | 18 |
| Tim Wakefield | Bos | sp | 42 | 4.58 | 11 | 5 | 0 | 21 | 21 | 2 | 0 | 129.2 | 137 | 67 | 66 | 50 | 72 | 12 | 13 |
| Chien-Ming Wang | NYA | sp | 29 | 9.64 | 1 | 6 | 0 | 12 | 9 | 0 | 0 | 42.0 | 66 | 46 | 45 | 19 | 29 | 7 | 5 |
| Jarrod Washburn* |   | sp | 34 | 3.78 | 9 | 9 | 0 | 28 | 28 | 1 | 1 | 176.0 | 160 | 77 | 74 | 49 | 100 | 23 | 16 |
| Jered Weaver | LAA | sp | 26 | 3.75 | 16 | 8 | 0 | 33 | 33 | 4 | 2 | 211.0 | 196 | 91 | 88 | 66 | 174 | 26 | 5 |
| Todd Wellemeyer | StL | sp | 30 | 5.89 | 7 | 10 | 0 | 28 | 21 | 0 | 0 | 122.1 | 160 | 88 | 80 | 57 | 78 | 19 | 20 |
| Randy Wells | ChN | sp | 26 | 3.05 | 12 | 10 | 0 | 27 | 27 | 0 | 0 | 165.1 | 165 | 67 | 56 | 46 | 104 | 14 | 20 |
| Sean West* | Flo | sp | 23 | 4.79 | 8 | 6 | 0 | 20 | 20 | 0 | 0 | 103.1 | 115 | 62 | 55 | 44 | 70 | 11 | 12 |
| Randy Wolf* | LAN | sp | 32 | 3.23 | 11 | 7 | 0 | 34 | 34 | 0 | 0 | 214.1 | 178 | 81 | 77 | 58 | 160 | 24 | 16 |
| Chris Young | SD | sp | 30 | 5.21 | 4 | 6 | 0 | 14 | 14 | 0 | 0 | 76.0 | 70 | 47 | 44 | 40 | 50 | 12 | 2 |
| Carlos Zambrano | ChN | sp | 28 | 3.77 | 9 | 7 | 0 | 28 | 28 | 1 | 1 | 169.1 | 155 | 78 | 71 | 78 | 152 | 10 | 8 |
| Jordan Zimmermann | Was | sp | 23 | 4.63 | 3 | 5 | 0 | 16 | 16 | 0 | 0 | 91.1 | 95 | 51 | 47 | 29 | 92 | 10 | 6 |
| Barry Zito* | SF | sp | 31 | 4.03 | 10 | 13 | 0 | 33 | 33 | 1 | 0 | 192.0 | 179 | 89 | 86 | 81 | 154 | 21 | 19 |
| Alfredo Aceves | NYA | mr | 26 | 3.54 | 10 | 1 | 1 | 43 | 1 | 0 | 0 | 84.0 | 69 | 36 | 33 | 16 | 69 | 10 | 5 |
| Jeremy Affeldt* | SF | mr | 30 | 1.73 | 2 | 2 | 0 | 74 | 0 | 0 | 0 | 62.1 | 42 | 14 | 12 | 31 | 55 | 3 | 18 |
| Matt Albers | Bal | mr | 26 | 5.51 | 3 | 6 | 0 | 56 | 0 | 0 | 0 | 67.0 | 80 | 43 | 41 | 36 | 49 | 3 | 8 |
| Alberto Arias | Hou | mr | 25 | 3.35 | 2 | 1 | 0 | 42 | 0 | 0 | 0 | 45.2 | 49 | 21 | 17 | 19 | 39 | 1 | 7 |
| Jose Arredondo | LAA | mr | 25 | 6.00 | 2 | 3 | 0 | 43 | 0 | 0 | 0 | 45.0 | 47 | 30 | 30 | 23 | 47 | 6 | 4 |
| Luis Ayala |   | mr | 31 | 5.63 | 1 | 5 | 0 | 38 | 0 | 0 | 0 | 40.0 | 50 | 28 | 25 | 14 | 28 | 5 | 7 |
| Burke Badenhop | Flo | mr | 26 | 3.75 | 7 | 4 | 0 | 35 | 2 | 0 | 0 | 72.0 | 71 | 32 | 30 | 24 | 57 | 5 | 11 |
| Danys Baez | Bal | mr | 31 | 4.02 | 4 | 6 | 0 | 59 | 0 | 0 | 0 | 71.2 | 59 | 36 | 32 | 22 | 40 | 8 | 9 |
| Grant Balfour | Tam | mr | 31 | 4.81 | 5 | 4 | 4 | 73 | 0 | 0 | 0 | 67.1 | 59 | 38 | 36 | 33 | 69 | 6 | 7 |
| Daniel Bard | Bos | mr | 24 | 3.65 | 2 | 2 | 1 | 49 | 0 | 0 | 0 | 49.1 | 41 | 24 | 20 | 22 | 63 | 5 | 4 |
| Brian Bass | Bal | mr | 27 | 4.90 | 5 | 3 | 0 | 48 | 0 | 0 | 0 | 86.1 | 106 | 52 | 47 | 44 | 54 | 11 | 10 |
| Miguel Batista | Sea | mr | 38 | 4.04 | 7 | 4 | 1 | 56 | 0 | 0 | 0 | 71.1 | 79 | 37 | 32 | 39 | 52 | 7 | 9 |
| Joe Beimel* |   | mr | 32 | 3.58 | 1 | 6 | 1 | 71 | 0 | 0 | 0 | 55.1 | 57 | 24 | 22 | 19 | 35 | 5 | 2 |
| Ronald Belisario | LAN | mr | 26 | 2.04 | 4 | 3 | 0 | 69 | 0 | 0 | 0 | 70.2 | 52 | 21 | 16 | 29 | 64 | 4 | 6 |
| Jeff Bennett |   | mr | 29 | 5.01 | 2 | 4 | 0 | 44 | 0 | 0 | 0 | 46.2 | 66 | 27 | 26 | 32 | 27 | 4 | 10 |
| Jason Bergmann | Was | mr | 27 | 4.50 | 2 | 4 | 0 | 56 | 0 | 0 | 0 | 48.0 | 50 | 28 | 24 | 25 | 40 | 7 | 8 |
| Rafael Betancourt |   | mr | 34 | 2.73 | 4 | 3 | 2 | 61 | 0 | 0 | 0 | 56.0 | 42 | 20 | 17 | 20 | 61 | 4 | 5 |
| Blaine Boyer |   | mr | 27 | 4.12 | 0 | 2 | 0 | 48 | 0 | 0 | 0 | 54.2 | 56 | 36 | 25 | 20 | 29 | 1 | 5 |
| Craig Breslow* |   | mr | 28 | 3.36 | 8 | 7 | 0 | 77 | 0 | 0 | 0 | 69.2 | 48 | 31 | 26 | 29 | 55 | 8 | 6 |
| Jason Bulger | LAA | mr | 30 | 3.56 | 6 | 1 | 1 | 64 | 0 | 0 | 0 | 65.2 | 46 | 26 | 26 | 30 | 68 | 7 | 11 |
| Greg Burke | SD | mr | 26 | 4.14 | 3 | 3 | 0 | 48 | 0 | 0 | 0 | 45.2 | 48 | 23 | 21 | 23 | 33 | 4 | 3 |
| Sean Burnett* |   | mr | 26 | 3.12 | 2 | 3 | 1 | 71 | 0 | 0 | 0 | 57.2 | 36 | 21 | 20 | 28 | 43 | 6 | 2 |
| Jared Burton | Cin | mr | 28 | 4.40 | 1 | 0 | 0 | 53 | 0 | 0 | 0 | 59.1 | 61 | 30 | 29 | 23 | 45 | 5 | 4 |
| Tim Byrdak* | Hou | mr | 35 | 3.23 | 1 | 2 | 0 | 76 | 0 | 0 | 0 | 61.1 | 39 | 23 | 22 | 36 | 58 | 10 | 2 |
| Kiko Calero | Flo | mr | 34 | 1.95 | 2 | 2 | 0 | 67 | 0 | 0 | 0 | 60.0 | 36 | 13 | 13 | 30 | 69 | 1 | 0 |
| Shawn Camp | Tor | mr | 33 | 3.50 | 2 | 6 | 1 | 59 | 0 | 0 | 0 | 79.2 | 73 | 36 | 31 | 29 | 58 | 7 | 12 |
| Jesse Carlson* | Tor | mr | 28 | 4.66 | 1 | 6 | 0 | 73 | 0 | 0 | 0 | 67.2 | 67 | 37 | 35 | 21 | 51 | 7 | 4 |
| D.J. Carrasco | ChA | mr | 32 | 3.76 | 5 | 1 | 0 | 49 | 1 | 0 | 0 | 93.1 | 103 | 42 | 39 | 29 | 62 | 5 | 11 |
| Santiago Casilla | Oak | mr | 28 | 5.96 | 1 | 2 | 0 | 46 | 0 | 0 | 0 | 48.1 | 61 | 36 | 32 | 25 | 35 | 6 | 3 |
| Jesse Chavez | Pit | mr | 25 | 4.01 | 1 | 4 | 0 | 73 | 0 | 0 | 0 | 67.1 | 69 | 33 | 30 | 22 | 47 | 11 | 2 |
| Tyler Clippard | Was | mr | 24 | 2.69 | 4 | 2 | 0 | 41 | 0 | 0 | 0 | 60.1 | 36 | 20 | 18 | 32 | 67 | 9 | 3 |
| Todd Coffey | Mil | mr | 28 | 2.90 | 4 | 4 | 2 | 78 | 0 | 0 | 0 | 83.2 | 76 | 28 | 27 | 21 | 65 | 8 | 12 |
| Phil Coke* | NYA | mr | 26 | 4.50 | 4 | 3 | 2 | 72 | 0 | 0 | 0 | 60.0 | 44 | 34 | 30 | 20 | 49 | 10 | 6 |
| Roman Colon | KC | mr | 29 | 4.83 | 2 | 3 | 0 | 43 | 0 | 0 | 0 | 50.1 | 50 | 27 | 27 | 22 | 29 | 7 | 4 |
| Lance Cormier | Tam | mr | 28 | 3.26 | 3 | 3 | 2 | 53 | 0 | 0 | 0 | 77.1 | 75 | 31 | 28 | 25 | 36 | 6 | 6 |
| Jesse Crain | Min | mr | 27 | 4.70 | 7 | 4 | 0 | 56 | 0 | 0 | 0 | 51.2 | 48 | 28 | 27 | 27 | 43 | 3 | 5 |
| Juan Cruz | KC | mr | 30 | 5.72 | 3 | 4 | 2 | 46 | 0 | 0 | 0 | 50.1 | 46 | 34 | 32 | 29 | 38 | 6 | 3 |
| Matt Daley | Col | mr | 27 | 4.24 | 1 | 1 | 0 | 57 | 0 | 0 | 0 | 51.0 | 43 | 24 | 24 | 18 | 55 | 6 | 2 |
| Manny Delcarmen | Bos | mr | 27 | 4.53 | 5 | 2 | 0 | 64 | 0 | 0 | 0 | 59.2 | 64 | 34 | 30 | 34 | 44 | 5 | 3 |
| R.A. Dickey | Min | mr | 34 | 4.62 | 1 | 1 | 0 | 35 | 1 | 0 | 0 | 64.1 | 74 | 34 | 33 | 30 | 42 | 8 | 5 |
| Mark DiFelice | Mil | mr | 32 | 3.66 | 4 | 1 | 0 | 59 | 0 | 0 | 0 | 51.2 | 49 | 21 | 21 | 15 | 48 | 6 | 1 |
| Octavio Dotel | ChA | mr | 35 | 3.32 | 3 | 3 | 0 | 62 | 0 | 0 | 0 | 62.1 | 54 | 26 | 23 | 36 | 75 | 7 | 3 |
| Scott Downs* | Tor | mr | 33 | 3.09 | 1 | 3 | 9 | 48 | 0 | 0 | 0 | 46.2 | 46 | 18 | 16 | 13 | 43 | 4 | 3 |
| Brian Duensing* | Min | mr | 26 | 3.64 | 5 | 2 | 0 | 24 | 9 | 0 | 0 | 84.0 | 84 | 37 | 34 | 31 | 53 | 7 | 10 |
| Chad Durbin | Phi | mr | 31 | 4.39 | 2 | 2 | 2 | 59 | 0 | 0 | 0 | 69.2 | 56 | 38 | 34 | 47 | 62 | 8 | 3 |
| Pedro Feliciano* | NYN | mr | 32 | 3.19 | 6 | 4 | 0 | 88 | 0 | 0 | 0 | 59.1 | 51 | 25 | 21 | 18 | 59 | 7 | 5 |
| Carlos Fisher | Cin | mr | 26 | 4.47 | 1 | 1 | 0 | 39 | 0 | 0 | 0 | 52.1 | 50 | 26 | 26 | 31 | 48 | 4 | 6 |
| Josh Fogg | Col | mr | 32 | 3.74 | 0 | 2 | 0 | 24 | 1 | 0 | 0 | 45.2 | 32 | 20 | 19 | 20 | 27 | 7 | 5 |
| Jason Frasor | Tor | mr | 31 | 2.50 | 7 | 3 | 11 | 61 | 0 | 0 | 0 | 57.2 | 43 | 17 | 16 | 16 | 56 | 4 | 4 |
| Jeff Fulchino | Hou | mr | 29 | 3.40 | 6 | 4 | 0 | 61 | 0 | 0 | 0 | 82.0 | 70 | 33 | 31 | 27 | 71 | 7 | 5 |
| Edgar Gonzalez | Oak | mr | 26 | 5.51 | 0 | 4 | 0 | 26 | 6 | 0 | 0 | 65.1 | 76 | 41 | 40 | 28 | 39 | 4 | 5 |
| Mike Gonzalez* | Atl | mr | 31 | 2.42 | 5 | 4 | 10 | 80 | 0 | 0 | 0 | 74.1 | 56 | 28 | 20 | 33 | 90 | 7 | 6 |
| Tom Gorzelanny* |   | mr | 26 | 5.55 | 7 | 3 | 0 | 22 | 7 | 0 | 0 | 47.0 | 45 | 30 | 29 | 17 | 47 | 6 | 2 |
| John Grabow* |   | mr | 30 | 3.36 | 3 | 0 | 0 | 75 | 0 | 0 | 0 | 72.1 | 62 | 28 | 27 | 40 | 57 | 5 | 8 |
| Sean Green | NYN | mr | 30 | 4.39 | 1 | 4 | 1 | 79 | 0 | 0 | 0 | 69.2 | 64 | 37 | 34 | 36 | 54 | 5 | 7 |
| Luke Gregerson | SD | mr | 25 | 3.24 | 2 | 4 | 1 | 72 | 0 | 0 | 0 | 75.0 | 62 | 29 | 27 | 31 | 93 | 3 | 5 |
| Jason Grilli |   | mr | 32 | 5.32 | 2 | 3 | 1 | 52 | 0 | 0 | 0 | 45.2 | 50 | 27 | 27 | 27 | 49 | 4 | 2 |
| Matt Guerrier | Min | mr | 30 | 2.36 | 5 | 1 | 1 | 79 | 0 | 0 | 0 | 76.1 | 58 | 23 | 20 | 16 | 47 | 10 | 5 |
| Juan Gutierrez | Ari | mr | 25 | 4.06 | 4 | 3 | 9 | 65 | 0 | 0 | 0 | 71.0 | 67 | 33 | 32 | 30 | 66 | 2 | 5 |
| Angel Guzman | ChN | mr | 27 | 2.95 | 3 | 3 | 1 | 55 | 0 | 0 | 0 | 61.0 | 41 | 20 | 20 | 23 | 47 | 8 | 4 |
| Joel Hanrahan |   | mr | 27 | 4.78 | 1 | 4 | 5 | 67 | 0 | 0 | 0 | 64.0 | 73 | 40 | 34 | 34 | 72 | 3 | 2 |
| LaTroy Hawkins | Hou | mr | 36 | 2.13 | 1 | 4 | 11 | 65 | 0 | 0 | 0 | 63.1 | 60 | 16 | 15 | 16 | 45 | 7 | 7 |
| Aaron Heilman | ChN | mr | 30 | 4.11 | 4 | 4 | 1 | 70 | 0 | 0 | 0 | 72.1 | 68 | 34 | 33 | 34 | 65 | 9 | 7 |
| Mark Hendrickson* | Bal | mr | 35 | 4.37 | 6 | 5 | 1 | 53 | 11 | 0 | 0 | 105.0 | 116 | 59 | 51 | 33 | 61 | 16 | 8 |
| Daniel Ray Herrera* | Cin | mr | 24 | 3.06 | 4 | 4 | 0 | 70 | 0 | 0 | 0 | 61.2 | 63 | 30 | 21 | 24 | 44 | 5 | 10 |
| J.P. Howell* | Tam | mr | 26 | 2.83 | 7 | 5 | 17 | 69 | 0 | 0 | 0 | 66.2 | 47 | 22 | 21 | 33 | 79 | 7 | 5 |
| Bob Howry | SF | mr | 35 | 3.39 | 2 | 6 | 0 | 63 | 0 | 0 | 0 | 63.2 | 50 | 26 | 24 | 23 | 46 | 5 | 2 |
| Phil Hughes | NYA | mr | 23 | 3.03 | 8 | 3 | 3 | 51 | 7 | 0 | 0 | 86.0 | 68 | 31 | 29 | 28 | 96 | 8 | 6 |
| Steven Jackson | Pit | mr | 27 | 3.14 | 2 | 3 | 0 | 40 | 0 | 0 | 0 | 43.0 | 38 | 20 | 15 | 22 | 21 | 2 | 3 |
| Chris Jakubauskas | Sea | mr | 30 | 5.32 | 6 | 7 | 0 | 35 | 8 | 1 | 0 | 93.0 | 91 | 60 | 55 | 27 | 47 | 15 | 7 |
| Casey Janssen | Tor | mr | 27 | 5.85 | 2 | 4 | 1 | 21 | 5 | 0 | 0 | 40.0 | 59 | 29 | 26 | 14 | 24 | 5 | 6 |
| Jason Jennings | Tex | mr | 30 | 4.13 | 2 | 4 | 1 | 44 | 0 | 0 | 0 | 61.0 | 67 | 31 | 28 | 28 | 44 | 7 | 7 |
| Kevin Jepsen | LAA | mr | 24 | 4.94 | 6 | 4 | 1 | 54 | 0 | 0 | 0 | 54.2 | 63 | 33 | 30 | 19 | 48 | 2 | 6 |
| Jim Johnson | Bal | mr | 26 | 4.11 | 4 | 6 | 10 | 64 | 0 | 0 | 0 | 70.0 | 73 | 32 | 32 | 23 | 49 | 8 | 11 |
| Jeff Karstens | Pit | mr | 26 | 5.42 | 4 | 6 | 0 | 39 | 13 | 0 | 0 | 108.0 | 115 | 66 | 65 | 45 | 52 | 12 | 9 |
| Shawn Kelley | Sea | mr | 25 | 4.50 | 5 | 4 | 0 | 41 | 0 | 0 | 0 | 46.0 | 45 | 23 | 23 | 9 | 41 | 9 | 4 |
| Bob Keppel | Min | mr | 27 | 4.83 | 1 | 1 | 0 | 37 | 0 | 0 | 0 | 54.0 | 63 | 30 | 29 | 21 | 32 | 4 | 3 |
| Brandon League | Tor | mr | 26 | 4.58 | 3 | 6 | 0 | 67 | 0 | 0 | 0 | 74.2 | 72 | 40 | 38 | 21 | 76 | 8 | 12 |
| Jensen Lewis | Cle | mr | 25 | 4.61 | 2 | 4 | 1 | 47 | 0 | 0 | 0 | 66.1 | 62 | 37 | 34 | 29 | 62 | 13 | 5 |
| Scott Linebrink | ChA | mr | 32 | 4.66 | 3 | 7 | 2 | 57 | 0 | 0 | 0 | 56.0 | 70 | 34 | 29 | 23 | 55 | 9 | 3 |
| Shane Loux | LAA | mr | 29 | 5.86 | 2 | 3 | 0 | 18 | 6 | 0 | 0 | 58.1 | 84 | 42 | 38 | 19 | 19 | 4 | 8 |
| Mark Lowe | Sea | mr | 26 | 3.26 | 2 | 7 | 3 | 75 | 0 | 0 | 0 | 80.0 | 71 | 39 | 29 | 29 | 69 | 7 | 5 |
| Brandon Lyon | Det | mr | 29 | 2.86 | 6 | 5 | 3 | 65 | 0 | 0 | 0 | 78.2 | 56 | 25 | 25 | 31 | 57 | 7 | 7 |
| Ryan Madson | Phi | mr | 28 | 3.26 | 5 | 5 | 10 | 79 | 0 | 0 | 0 | 77.1 | 73 | 29 | 28 | 22 | 78 | 7 | 8 |
| Ron Mahay* |   | mr | 38 | 4.29 | 2 | 1 | 0 | 57 | 0 | 0 | 0 | 50.1 | 62 | 29 | 24 | 22 | 42 | 10 | 4 |
| Carlos Marmol | ChN | mr | 26 | 3.41 | 2 | 4 | 15 | 79 | 0 | 0 | 0 | 74.0 | 43 | 29 | 28 | 65 | 93 | 2 | 7 |
| Sean Marshall* | ChN | mr | 26 | 4.32 | 3 | 7 | 0 | 55 | 9 | 1 | 0 | 85.1 | 91 | 43 | 41 | 32 | 68 | 10 | 6 |
| Nick Masset | Cin | mr | 27 | 2.37 | 5 | 1 | 0 | 74 | 0 | 0 | 0 | 76.0 | 54 | 22 | 20 | 24 | 70 | 6 | 11 |
| Justin Masterson |   | mr | 24 | 4.52 | 4 | 10 | 0 | 42 | 16 | 1 | 0 | 129.1 | 128 | 73 | 65 | 60 | 119 | 12 | 15 |
| Kyle McClellan | StL | mr | 25 | 3.38 | 4 | 4 | 3 | 66 | 0 | 0 | 0 | 66.2 | 56 | 27 | 25 | 34 | 51 | 4 | 8 |
| Seth McClung | Mil | mr | 28 | 4.94 | 3 | 3 | 0 | 41 | 2 | 0 | 0 | 62.0 | 62 | 34 | 34 | 39 | 40 | 11 | 7 |
| James McDonald | LAN | mr | 24 | 4.00 | 5 | 5 | 0 | 45 | 4 | 0 | 0 | 63.0 | 60 | 34 | 28 | 34 | 54 | 6 | 5 |
| Brandon Medders | SF | mr | 29 | 3.01 | 5 | 1 | 1 | 61 | 0 | 0 | 0 | 68.2 | 63 | 26 | 23 | 32 | 58 | 6 | 3 |
| Kris Medlen | Atl | mr | 23 | 4.26 | 3 | 5 | 0 | 37 | 4 | 0 | 0 | 67.2 | 65 | 34 | 32 | 30 | 72 | 5 | 5 |
| Evan Meek | Pit | mr | 26 | 3.45 | 1 | 1 | 0 | 41 | 0 | 0 | 0 | 47.0 | 34 | 18 | 18 | 29 | 42 | 2 | 6 |
| Cla Meredith |   | mr | 26 | 3.99 | 4 | 2 | 0 | 64 | 0 | 0 | 0 | 65.1 | 73 | 31 | 29 | 25 | 37 | 4 | 11 |
| Dan Meyer* | Flo | mr | 27 | 3.09 | 3 | 2 | 2 | 71 | 0 | 0 | 0 | 58.1 | 47 | 24 | 20 | 21 | 56 | 7 | 4 |
| Jose Mijares* | Min | mr | 24 | 2.34 | 2 | 2 | 0 | 71 | 0 | 0 | 0 | 61.2 | 50 | 17 | 16 | 23 | 55 | 7 | 5 |
| Justin Miller | SF | mr | 31 | 3.18 | 3 | 3 | 0 | 44 | 0 | 0 | 0 | 56.2 | 47 | 20 | 20 | 27 | 36 | 7 | 5 |
| Zach Miner | Det | mr | 27 | 4.29 | 7 | 5 | 1 | 51 | 5 | 0 | 0 | 92.1 | 101 | 49 | 44 | 45 | 62 | 11 | 14 |
| Pat Misch* |   | mr | 27 | 4.48 | 3 | 4 | 0 | 26 | 7 | 1 | 1 | 62.1 | 68 | 31 | 31 | 22 | 23 | 9 | 4 |
| Franklin Morales* | Col | mr | 23 | 4.50 | 3 | 2 | 7 | 40 | 2 | 0 | 0 | 40.0 | 38 | 22 | 20 | 23 | 41 | 4 | 3 |
| Guillermo Mota | LAN | mr | 35 | 3.44 | 3 | 4 | 0 | 61 | 0 | 0 | 0 | 65.1 | 53 | 25 | 25 | 24 | 39 | 6 | 5 |
| Jason Motte | StL | mr | 27 | 4.76 | 4 | 4 | 0 | 69 | 0 | 0 | 0 | 56.2 | 57 | 32 | 30 | 23 | 54 | 10 | 6 |
| Peter Moylan | Atl | mr | 30 | 2.84 | 6 | 2 | 0 | 87 | 0 | 0 | 0 | 73.0 | 65 | 29 | 23 | 35 | 61 | 0 | 12 |
| Edward Mujica | SD | mr | 25 | 3.94 | 3 | 5 | 2 | 67 | 4 | 0 | 0 | 93.2 | 101 | 47 | 41 | 19 | 76 | 14 | 8 |
| Chris Narveson* | Mil | mr | 27 | 3.83 | 2 | 0 | 0 | 21 | 4 | 0 | 0 | 47.0 | 45 | 22 | 20 | 16 | 46 | 7 | 1 |
| Joe Nelson | Tam | mr | 34 | 4.02 | 3 | 0 | 3 | 42 | 0 | 0 | 0 | 40.1 | 32 | 22 | 18 | 27 | 36 | 7 | 2 |
| Darren O'Day |   | mr | 26 | 1.84 | 2 | 1 | 2 | 68 | 0 | 0 | 0 | 58.2 | 41 | 14 | 12 | 18 | 56 | 3 | 6 |
| Eric O'Flaherty* | Atl | mr | 24 | 3.04 | 2 | 1 | 0 | 78 | 0 | 0 | 0 | 56.1 | 52 | 23 | 19 | 18 | 39 | 2 | 5 |
| Tomo Ohka | Cle | mr | 33 | 5.96 | 1 | 5 | 0 | 18 | 6 | 0 | 0 | 71.0 | 77 | 47 | 47 | 19 | 31 | 18 | 5 |
| Hideki Okajima* | Bos | mr | 33 | 3.39 | 6 | 0 | 0 | 68 | 0 | 0 | 0 | 61.0 | 56 | 23 | 23 | 21 | 53 | 8 | 2 |
| Darren Oliver* | LAA | mr | 38 | 2.71 | 5 | 1 | 0 | 63 | 1 | 0 | 0 | 73.0 | 61 | 22 | 22 | 22 | 65 | 5 | 7 |
| Garrett Olson* | Sea | mr | 25 | 5.60 | 3 | 5 | 0 | 31 | 11 | 0 | 0 | 80.1 | 79 | 52 | 50 | 34 | 47 | 19 | 9 |
| Matt Palmer | LAA | mr | 30 | 3.93 | 11 | 2 | 0 | 40 | 13 | 1 | 0 | 121.1 | 105 | 55 | 53 | 55 | 69 | 12 | 20 |
| Chan Ho Park | Phi | mr | 36 | 4.43 | 3 | 3 | 0 | 45 | 7 | 0 | 0 | 83.1 | 84 | 43 | 41 | 33 | 73 | 5 | 7 |
| Bobby Parnell | NYN | mr | 24 | 5.30 | 4 | 8 | 1 | 68 | 8 | 0 | 0 | 88.1 | 101 | 56 | 52 | 46 | 74 | 8 | 6 |
| Tony Pena |   | mr | 27 | 3.99 | 6 | 5 | 2 | 72 | 0 | 0 | 0 | 70.0 | 81 | 37 | 31 | 20 | 55 | 7 | 4 |
| Luis Perdomo | SD | mr | 25 | 4.80 | 1 | 0 | 0 | 35 | 0 | 0 | 0 | 60.0 | 57 | 36 | 32 | 34 | 55 | 11 | 3 |
| Chris Perez |   | mr | 23 | 4.26 | 1 | 2 | 2 | 61 | 0 | 0 | 0 | 57.0 | 41 | 28 | 27 | 27 | 68 | 8 | 4 |
| Rafael Perez* | Cle | mr | 27 | 7.31 | 4 | 3 | 0 | 54 | 0 | 0 | 0 | 48.0 | 66 | 41 | 39 | 25 | 32 | 5 | 9 |
| Ryan Perry | Det | mr | 22 | 3.79 | 0 | 1 | 0 | 53 | 0 | 0 | 0 | 61.2 | 56 | 30 | 26 | 38 | 60 | 7 | 7 |
| Renyel Pinto* | Flo | mr | 26 | 3.23 | 4 | 1 | 0 | 73 | 0 | 0 | 0 | 61.1 | 53 | 25 | 22 | 45 | 58 | 4 | 7 |
| Ramon Ramirez | Bos | mr | 27 | 2.84 | 7 | 4 | 0 | 70 | 0 | 0 | 0 | 69.2 | 61 | 26 | 22 | 32 | 52 | 7 | 7 |
| Jon Rauch |   | mr | 30 | 3.60 | 7 | 3 | 2 | 75 | 0 | 0 | 0 | 70.0 | 70 | 30 | 28 | 23 | 49 | 6 | 7 |
| Chris Ray | Bal | mr | 27 | 7.27 | 0 | 4 | 0 | 46 | 0 | 0 | 0 | 43.1 | 64 | 36 | 35 | 23 | 39 | 8 | 4 |
| Dennys Reyes* | StL | mr | 32 | 3.29 | 0 | 2 | 1 | 75 | 0 | 0 | 0 | 41.0 | 35 | 17 | 15 | 21 | 33 | 2 | 1 |
| Arthur Rhodes* | Cin | mr | 39 | 2.53 | 1 | 1 | 0 | 66 | 0 | 0 | 0 | 53.1 | 37 | 16 | 15 | 20 | 48 | 3 | 3 |
| David Robertson | NYA | mr | 24 | 3.30 | 2 | 1 | 1 | 45 | 0 | 0 | 0 | 43.2 | 36 | 19 | 16 | 23 | 63 | 4 | 0 |
| Nate Robertson* | Det | mr | 31 | 5.44 | 2 | 3 | 0 | 28 | 6 | 0 | 0 | 49.2 | 59 | 33 | 30 | 28 | 35 | 4 | 6 |
| Leo Rosales | Ari | mr | 28 | 4.76 | 2 | 1 | 0 | 33 | 0 | 0 | 0 | 45.1 | 40 | 24 | 24 | 12 | 31 | 5 | 3 |
| Takashi Saito | Bos | mr | 39 | 2.43 | 3 | 3 | 2 | 56 | 0 | 0 | 0 | 55.2 | 50 | 16 | 15 | 25 | 52 | 6 | 3 |
| Chris Sampson | Hou | mr | 31 | 5.04 | 4 | 2 | 3 | 49 | 0 | 0 | 0 | 55.1 | 66 | 34 | 31 | 21 | 33 | 2 | 5 |
| Brian Sanches | Flo | mr | 30 | 2.56 | 4 | 2 | 0 | 47 | 0 | 0 | 0 | 56.1 | 50 | 18 | 16 | 26 | 51 | 5 | 3 |
| Bobby Seay* | Det | mr | 31 | 4.25 | 6 | 3 | 0 | 67 | 0 | 0 | 0 | 48.2 | 46 | 23 | 23 | 17 | 37 | 3 | 3 |
| Chris Smith | Mil | mr | 28 | 4.11 | 0 | 0 | 0 | 35 | 0 | 0 | 0 | 46.0 | 41 | 21 | 21 | 19 | 35 | 11 | 4 |
| Justin Speier | LAA | mr | 35 | 5.17 | 4 | 2 | 0 | 41 | 0 | 0 | 0 | 40.0 | 44 | 23 | 23 | 15 | 39 | 7 | 2 |
| Russ Springer |   | mr | 40 | 4.11 | 1 | 4 | 1 | 74 | 0 | 0 | 0 | 57.0 | 68 | 27 | 26 | 17 | 58 | 9 | 1 |
| Mitch Stetter* | Mil | mr | 28 | 3.60 | 4 | 1 | 1 | 71 | 0 | 0 | 0 | 45.0 | 37 | 19 | 18 | 27 | 44 | 4 | 2 |
| Brian Stokes | NYN | mr | 29 | 3.97 | 2 | 4 | 0 | 69 | 0 | 0 | 0 | 70.1 | 72 | 33 | 31 | 38 | 45 | 6 | 13 |
| Robinson Tejeda | KC | mr | 27 | 3.54 | 4 | 2 | 0 | 35 | 6 | 0 | 0 | 73.2 | 43 | 30 | 29 | 50 | 87 | 4 | 4 |
| Joe Thatcher* | SD | mr | 27 | 2.80 | 1 | 0 | 0 | 52 | 0 | 0 | 0 | 45.0 | 37 | 14 | 14 | 18 | 55 | 2 | 4 |
| Brad Thompson | StL | mr | 27 | 4.84 | 2 | 6 | 0 | 32 | 8 | 0 | 0 | 80.0 | 85 | 45 | 43 | 23 | 34 | 8 | 12 |
| Matt Thornton* | ChA | mr | 32 | 2.74 | 6 | 3 | 4 | 70 | 0 | 0 | 0 | 72.1 | 58 | 22 | 22 | 20 | 87 | 5 | 3 |
| Brett Tomko |   | mr | 36 | 3.77 | 5 | 3 | 0 | 21 | 6 | 1 | 1 | 57.1 | 50 | 24 | 24 | 13 | 33 | 12 | 6 |
| Ramon Troncoso | LAN | mr | 26 | 2.72 | 5 | 4 | 6 | 73 | 0 | 0 | 0 | 82.2 | 83 | 30 | 25 | 34 | 55 | 3 | 10 |
| Merkin Valdez | SF | mr | 27 | 5.66 | 2 | 1 | 0 | 48 | 0 | 0 | 0 | 49.1 | 57 | 33 | 31 | 28 | 38 | 5 | 7 |
| Esmerling Vasquez | Ari | mr | 25 | 4.42 | 3 | 3 | 0 | 53 | 0 | 0 | 0 | 53.0 | 52 | 27 | 26 | 29 | 45 | 4 | 4 |
| Jose Veras |   | mr | 28 | 5.19 | 4 | 3 | 0 | 47 | 0 | 0 | 0 | 50.1 | 42 | 33 | 29 | 28 | 40 | 8 | 3 |
| Carlos Villanueva | Mil | mr | 25 | 5.34 | 4 | 10 | 3 | 64 | 6 | 0 | 0 | 96.0 | 102 | 58 | 57 | 35 | 83 | 13 | 10 |
| Ron Villone* | Was | mr | 39 | 4.25 | 5 | 6 | 1 | 63 | 0 | 0 | 0 | 48.2 | 54 | 25 | 23 | 29 | 33 | 6 | 3 |
| David Weathers |   | mr | 39 | 3.92 | 4 | 6 | 1 | 68 | 0 | 0 | 0 | 62.0 | 53 | 29 | 27 | 28 | 37 | 10 | 6 |
| Jeff Weaver | LAN | mr | 32 | 3.65 | 6 | 4 | 0 | 28 | 7 | 0 | 0 | 79.0 | 87 | 34 | 32 | 33 | 64 | 7 | 4 |
| Kip Wells |   | mr | 32 | 5.33 | 2 | 5 | 2 | 33 | 7 | 0 | 0 | 72.2 | 60 | 43 | 43 | 40 | 43 | 6 | 5 |
| Dan Wheeler | Tam | mr | 31 | 3.28 | 4 | 5 | 2 | 69 | 0 | 0 | 0 | 57.2 | 41 | 22 | 21 | 9 | 45 | 11 | 3 |
| Sean White | Sea | mr | 28 | 2.80 | 3 | 2 | 1 | 52 | 0 | 0 | 0 | 64.1 | 50 | 23 | 20 | 20 | 28 | 3 | 5 |
| C.J. Wilson* | Tex | mr | 28 | 2.81 | 5 | 6 | 14 | 74 | 0 | 0 | 0 | 73.2 | 66 | 29 | 23 | 32 | 84 | 3 | 5 |
| Jamey Wright | KC | mr | 34 | 4.33 | 3 | 5 | 0 | 65 | 0 | 0 | 0 | 79.0 | 73 | 51 | 38 | 44 | 60 | 8 | 11 |
| Wesley Wright* | Hou | mr | 24 | 5.44 | 3 | 4 | 0 | 49 | 0 | 0 | 0 | 44.2 | 53 | 27 | 27 | 25 | 47 | 9 | 5 |
| Michael Wuertz | Oak | mr | 30 | 2.63 | 6 | 1 | 4 | 74 | 0 | 0 | 0 | 78.2 | 52 | 25 | 23 | 23 | 102 | 6 | 3 |
| Clay Zavada* | Ari | mr | 25 | 3.35 | 3 | 3 | 0 | 49 | 0 | 0 | 0 | 51.0 | 45 | 22 | 19 | 24 | 52 | 5 | 2 |
| Brad Ziegler | Oak | mr | 29 | 3.07 | 2 | 4 | 7 | 69 | 0 | 0 | 0 | 73.1 | 82 | 27 | 25 | 28 | 54 | 2 | 14 |
| David Aardsma | Sea | cl | 27 | 2.52 | 3 | 6 | 38 | 73 | 0 | 0 | 0 | 71.1 | 49 | 23 | 20 | 34 | 80 | 4 | 2 |
| Andrew Bailey | Oak | cl | 25 | 1.84 | 6 | 3 | 26 | 68 | 0 | 0 | 0 | 83.1 | 49 | 17 | 17 | 24 | 91 | 5 | 3 |
| Heath Bell | SD | cl | 31 | 2.71 | 6 | 4 | 42 | 68 | 0 | 0 | 0 | 69.2 | 54 | 21 | 21 | 24 | 79 | 3 | 7 |
| Jonathan Broxton | LAN | cl | 25 | 2.61 | 7 | 2 | 36 | 73 | 0 | 0 | 0 | 76.0 | 44 | 24 | 22 | 29 | 114 | 4 | 1 |
| Matt Capps | Pit | cl | 25 | 5.80 | 4 | 8 | 27 | 57 | 0 | 0 | 0 | 54.1 | 73 | 36 | 35 | 17 | 46 | 10 | 7 |
| Francisco Cordero | Cin | cl | 34 | 2.16 | 2 | 6 | 39 | 68 | 0 | 0 | 0 | 66.2 | 58 | 21 | 16 | 30 | 58 | 2 | 7 |
| Frank Francisco | Tex | cl | 29 | 3.83 | 2 | 3 | 25 | 51 | 0 | 0 | 0 | 49.1 | 40 | 21 | 21 | 15 | 57 | 6 | 1 |
| Ryan Franklin | StL | cl | 36 | 1.92 | 4 | 3 | 38 | 62 | 0 | 0 | 0 | 61.0 | 49 | 13 | 13 | 24 | 44 | 2 | 4 |
| Brian Fuentes* | LAA | cl | 33 | 3.93 | 1 | 5 | 48 | 65 | 0 | 0 | 0 | 55.0 | 53 | 24 | 24 | 24 | 46 | 6 | 4 |
| Kevin Gregg | ChN | cl | 31 | 4.72 | 5 | 6 | 23 | 72 | 0 | 0 | 0 | 68.2 | 60 | 38 | 36 | 30 | 71 | 13 | 5 |
| Trevor Hoffman | Mil | cl | 41 | 1.83 | 3 | 2 | 37 | 55 | 0 | 0 | 0 | 54.0 | 35 | 11 | 11 | 14 | 48 | 2 | 3 |
| Bobby Jenks | ChA | cl | 28 | 3.71 | 3 | 4 | 29 | 52 | 0 | 0 | 0 | 53.1 | 52 | 24 | 22 | 16 | 49 | 9 | 4 |
| Brad Lidge | Phi | cl | 32 | 7.21 | 0 | 8 | 31 | 67 | 0 | 0 | 0 | 58.2 | 72 | 51 | 47 | 34 | 61 | 11 | 4 |
| Matt Lindstrom | Flo | cl | 29 | 5.89 | 2 | 1 | 15 | 54 | 0 | 0 | 0 | 47.1 | 54 | 35 | 31 | 24 | 39 | 5 | 4 |
| Mike MacDougal |   | cl | 32 | 4.31 | 1 | 1 | 20 | 57 | 0 | 0 | 0 | 54.1 | 52 | 31 | 26 | 38 | 34 | 3 | 12 |
| Brandon Morrow | Sea | cl | 24 | 4.39 | 2 | 4 | 6 | 26 | 10 | 0 | 0 | 69.2 | 66 | 38 | 34 | 44 | 63 | 10 | 5 |
| Joe Nathan | Min | cl | 34 | 2.10 | 2 | 2 | 47 | 70 | 0 | 0 | 0 | 68.2 | 42 | 16 | 16 | 22 | 89 | 7 | 2 |
| Leo Nunez | Flo | cl | 25 | 4.06 | 4 | 6 | 26 | 75 | 0 | 0 | 0 | 68.2 | 59 | 33 | 31 | 27 | 60 | 13 | 5 |
| Jonathan Papelbon | Bos | cl | 28 | 1.85 | 1 | 1 | 38 | 66 | 0 | 0 | 0 | 68.0 | 54 | 15 | 14 | 24 | 76 | 5 | 0 |
| Chad Qualls | Ari | cl | 30 | 3.63 | 2 | 2 | 24 | 51 | 0 | 0 | 0 | 52.0 | 53 | 23 | 21 | 7 | 45 | 5 | 5 |
| Mariano Rivera | NYA | cl | 39 | 1.76 | 3 | 3 | 44 | 66 | 0 | 0 | 0 | 66.1 | 48 | 14 | 13 | 12 | 72 | 7 | 3 |
| Fernando Rodney | Det | cl | 32 | 4.40 | 2 | 5 | 37 | 73 | 0 | 0 | 0 | 75.2 | 70 | 38 | 37 | 41 | 61 | 8 | 12 |
| Francisco Rodriguez | NYN | cl | 27 | 3.71 | 3 | 6 | 35 | 70 | 0 | 0 | 0 | 68.0 | 51 | 34 | 28 | 38 | 73 | 7 | 2 |
| George Sherrill* |   | cl | 32 | 1.70 | 1 | 1 | 21 | 72 | 0 | 0 | 0 | 69.0 | 53 | 13 | 13 | 24 | 61 | 4 | 4 |
| Joakim Soria | KC | cl | 25 | 2.21 | 3 | 2 | 30 | 47 | 0 | 0 | 0 | 53.0 | 44 | 14 | 13 | 16 | 69 | 5 | 3 |
| Rafael Soriano | Atl | cl | 29 | 2.97 | 1 | 6 | 27 | 77 | 0 | 0 | 0 | 75.2 | 53 | 25 | 25 | 27 | 102 | 6 | 4 |
| Huston Street | Col | cl | 25 | 3.06 | 4 | 1 | 35 | 64 | 0 | 0 | 0 | 61.2 | 43 | 22 | 21 | 13 | 70 | 7 | 1 |
| Jose Valverde | Hou | cl | 29 | 2.33 | 4 | 2 | 25 | 52 | 0 | 0 | 0 | 54.0 | 40 | 15 | 14 | 21 | 56 | 5 | 3 |
| Brian Wilson | SF | cl | 27 | 2.74 | 5 | 6 | 38 | 68 | 0 | 0 | 0 | 72.1 | 60 | 27 | 22 | 27 | 83 | 3 | 6 |
| Kerry Wood | Cle | cl | 32 | 4.25 | 3 | 3 | 20 | 58 | 0 | 0 | 0 | 55.0 | 48 | 26 | 26 | 28 | 63 | 7 | 4 |