| Transactions | ||||||
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/1/2010 | ACS | Santiago | Demoted to reserve roster | Before | ||
| 3/1/2010 | DMB | Gonzalez,G | Demoted to reserve roster | Before | ||
| 3/1/2010 | DMB | Hardy | Demoted to reserve roster | Before | ||
| 3/7/2010 | SS | Contreras | Promoted to active roster | Before | ||
| 3/7/2010 | SS | Ohlendorf | Demoted to reserve roster | Before | ||
| 3/8/2010 | DMB | Blanks | Acquired via trade | PL | After | |
| 3/8/2010 | DMB | Ethier | Traded away | PL | After | |
| 3/8/2010 | PL | Blanks | Traded away | DMB | After | |
| 3/8/2010 | PL | Ethier | Acquired via trade | DMB | After | |
| 3/9/2010 | PL | Hermida | Demoted to reserve roster | Before | ||
| 3/12/2010 | SS | Contreras | Demoted to reserve roster | Before | ||
| 3/12/2010 | SS | Ohlendorf | Promoted to active roster | Before | ||
| 3/17/2010 | End | Detwiler | Acquired via trade | ATT | After | |
| 3/17/2010 | End | Fox,J | Traded away | ATT | After | |
| 3/17/2010 | End | Matsuzaka | Traded away | ATT | After | |
| 3/17/2010 | End | Oswalt | Acquired via trade | ATT | After | |
| 3/17/2010 | End | Price | Traded away | ATT | After | |
| 3/17/2010 | End | Shoppach | Acquired via trade | ATT | After | |
| 3/17/2010 | ShS | Nolasco | Traded away | ATT | After | |
| 3/17/2010 | ShS | Pettitte | Acquired via trade | ATT | After | |
| 3/27/2010 | End | Bourn | Traded away | SS | After | |
| 3/27/2010 | End | Francisco,F | Traded away | SS | After | |
| 3/27/2010 | End | Nathan | Acquired via trade | SS | After | |
| 3/27/2010 | End | Ryan,BW | Acquired via trade | SS | After | |
| 3/27/2010 | SS | Bourn | Acquired via trade | End | After | |
| 3/27/2010 | SS | Francisco,F | Acquired via trade | End | After | |
| 3/27/2010 | SS | Nathan | Traded away | End | After | |
| 3/27/2010 | SS | Ryan,BW | Traded away | End | After | |
| 3/28/2010 | SS | Feliciano | Promoted to active roster | Before | ||
| 3/28/2010 | SS | Gomez | Demoted to reserve roster | Before | ||